ArticleCommunications biology2022
Convergence of virulence and antimicrobial resistance in increasingly prevalent Escherichia coli ST131 papGII+ sublineages.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 36 citations in OpenAlex.
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- Phylogenetic Groups, Virulence Factors, and Antimicrobial Susceptibility ofAntibiotics (Basel, Switzerland) · 2026Article
- Plasmid-Driven Resistome Diversity in 9700Antibiotics (Basel, Switzerland) · 2026Article
- Global epidemiological and genetic characteristics of carbapenem-resistantMicrobiology spectrum · 2026Article
- Genomic profiling of ESBL/AmpC-producingFrontiers in microbiology · 2026Article
- Whole-genome characterisation of high-risk ST131 and the emerging ST1193 UPEC lineages in Romanian patients with recurrent urinary tract infections.Frontiers in microbiology · 2026Article
- Prevalence, antimicrobial susceptibility, and virulence profiles of fluoroquinolone-resistant Escherichia coli isolated from companion animals in Sapporo, Japan.The Journal of veterinary medical science · 2025Article
- Virulence profiles and antibiotic resistance patterns ofOpen veterinary journal · 2025Article
- Comparative Analysis of ESBL Phenotypes and Antimicrobial Resistance inMicrobial drug resistance (Larchmont, N.Y.) · 2025Article
- How to measure bacterial genome plasticity? A novel index helps gather insights on pathogens.Microbial genomics · 2025Article
- Comprehensive Assessment of Initial Adaptation of Extended-Spectrum β-Lactamase-Positive ST131 Escherichia coli to Carbapenem Exposure.The Journal of infectious diseases · 2025Article
- An eco-evolutionary perspective on antimicrobial resistance in the context of One Health.iScience · 2025Review
- Colonization with resistant bacteria in hospital employees: an epidemiological surveillance and typing study.Antimicrobial agents and chemotherapy · 2024Article
- A Longitudinal Study ofMicroorganisms · 2024Article
- Genomic Epidemiology of C2/H30Rx and C1-M27 Subclades ofAntibiotics (Basel, Switzerland) · 2024Article
- A Decade-Long Evaluation of Neonatal Septicaemic Escherichia coli: Clonal Lineages, Genomes, and New Delhi Metallo-Beta-Lactamase Variants.Microbiology spectrum · 2023Article
- Uropathogenic Escherichia coli population structure and antimicrobial susceptibility in Norfolk, UK.The Journal of antimicrobial chemotherapy · 2023Article
- The bacterial genetic determinants of Escherichia coli capacity to cause bloodstream infections in humans.PLoS genetics · 2023Article
- Comparative Genomic Analysis of ST131 Subclade C2 of ESBL-ProducingMicroorganisms · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Escherichia coli lineage ST131 is an important cause of urinary tract and bloodstream infections worldwide and is highly resistant to antimicrobials. Specific ST131 lineages carrying invasiveness-associated papGII pathogenicity islands (PAIs) were previously described, but it is unknown how invasiveness relates to the acquisition of antimicrobial resistance (AMR). In this study, we analysed 1638 ST131 genomes and found that papGII+ isolates carry significantly more AMR genes than papGII-negative isolates, suggesting a convergence of virulence and AMR. The prevalence of papGII+ isolates among human clinical ST131 isolates increased dramatically since 2005, accounting for half of the recent E. coli bloodstream isolates. Emerging papGII+ lineages within clade C2 were characterized by a chromosomally integrated blaCTX-M-15 and the loss and replacement of F2:A1:B- plasmids. Convergence of virulence and AMR is worrying, and further dissemination of papGII+ ST131 lineages may lead to a rise in severe and difficult-to-treat extraintestinal infections.
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