Evidence map›Paper›PMID 35902682›Full record

ArticleCommunications biology2022

Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program.

Daniel DiCorpo, Sheila M Gaynor, Emily M Russell, Kenneth E Westerman, Laura M Raffield, Timothy D Majarian, Peitao Wu, Chloé Sarnowski, Heather M Highland, Anne Jackson and 83 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Global perspectives onFrontiers in pharmacology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

93 authors.

Daniel DiCorpo *Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.
Sheila M Gaynor *Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Emily M RussellDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Kenneth E WestermanClinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, 02114, USA.ORCID 0000-0001-7619-1868
Laura M RaffieldDepartment of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA.ORCID 0000-0002-7892-193X
Timothy D MajarianMetabolism Program, The Broad Institute of MIT and Harvard, Cambridge, MA, 02124, USA.
Peitao WuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.
Chloé SarnowskiDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.ORCID 0000-0002-6090-7099
Heather M HighlandDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA.ORCID 0000-0002-3583-8239
Anne JacksonDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA.
Natalie R HasbaniDepartment of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Paul S de VriesHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Jennifer A BrodyCardiovascular Health Research Unit, University of Washington, Seattle, WA, 98101, USA.
Bertha HidalgoRyals School of Public Health, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
James A PerryDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.ORCID 0000-0001-5050-2074
Jeffrey R O'ConnellDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Samantha LentDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.ORCID 0000-0003-0844-5621
May E MontasserDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.ORCID 0000-0002-9558-5456
Brian E CadeDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Deepti JainDepartment of Biostatistics, University of Washington, Seattle, WA, 98195, USA.
Heming WangDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Ricardo D'Oliveira AlbanusDepartment of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA.
Arushi VarshneyDepartment of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA.
Lisa R YanekGeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.ORCID 0000-0001-7117-1075
Leslie LangeDepartment of Medicine, Anschutz Medical Campus, University of Colorado Denver, Aurora, CO, 80045, USA.
Nicholette D PalmerDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.ORCID 0000-0001-8883-2511
Marcio AlmeidaDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville and Edinburg, TX, 78539, USA.
Juan M PeraltaDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville and Edinburg, TX, 78539, USA.
Stella Aslibekyan23andMe, Sunnyvale, CA, 94086, USA.
Abigail S BaldridgeDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Alain G BertoniDepartment of Epidemiology & Prevention, Wake Forest School of Medicine, Winston-, Salem, NC, 27157, USA.
Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Chung-Shiuan ChenDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, 70112, USA.
Yii-Der Ida ChenThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Won Jung ChoiPsomagen, Inc, Rockville, MD, 20850, USA.
Mark O GoodarziDepartment of Medicine, Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
James S FloydCardiovascular Health Research Unit, University of Washington, Seattle, WA, 98195, USA.
Marguerite R IrvinRyals School of Public Health, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Rita R KalyaniGeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Tanika N KellyDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, 70112, USA.
Seonwook LeePsomagen, Inc, Rockville, MD, 20850, USA.
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.ORCID 0000-0002-0703-0742
Douglas LoeschProgram for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
JoAnn E MansonDepartment of Medicine, Harvard Medical School, Boston, MA, 02115, USA.
Ryan L MinsterDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.ORCID 0000-0001-7382-6717
Take NaseriMinistry of Health, Government of Samoa, Apia, Samoa.
James S PankowDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, 55454, USA.
Laura J Rasmussen-TorvikDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Alexander P ReinerDepartment of Epidemiology, University of Washington, Seattle, WA, 98195, USA.
Muagututi'a Sefuiva ReupenaLutia i Puava 'ae Mapu i Fagalele, Apia, Samoa.
Elizabeth SelvinDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21287, USA.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-3575-5468
Daniel E WeeksDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Huichun XuDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Jie YaoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Stephen ParkerDepartment of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA.
Alvaro AlonsoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, 30322, USA.ORCID 0000-0002-2225-8323
Donna K ArnettCollege of Public Health, University of Kentucky, Lexington, KY, 40506, USA.ORCID 0000-0003-2219-657X
John BlangeroDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville and Edinburg, TX, 78539, USA.ORCID 0000-0001-6250-5723
Eric BoerwinkleDepartment of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Adolfo CorreaDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, 39211, USA.
L Adrienne CupplesDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.ORCID 0000-0003-0273-7965
Joanne E CurranDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville and Edinburg, TX, 78539, USA.ORCID 0000-0002-6898-155X
Ravindranath DuggiralaDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville and Edinburg, TX, 78539, USA.
Jiang HeDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, 70112, USA.
Susan R HeckbertCardiovascular Health Research Unit, University of Washington, Seattle, WA, 98195, USA.ORCID 0000-0002-7100-512X
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Ryan W KimPsomagen, Inc, Rockville, MD, 20850, USA.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.ORCID 0000-0002-7986-8560
Simin LiuCenter for Global Cardiometabolic Health (CGCH), Boston, MA, 02215, USA.ORCID 0000-0003-2098-3844
Rasika A MathiasGeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.ORCID 0000-0002-2282-9042
Stephen T McGarveyInternational Health Institute and Department of Epidemiology, Brown University School of Public Health, Providence, RI, 02912, USA.
Braxton D MitchellDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Alanna C MorrisonDepartment of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.ORCID 0000-0001-6381-4296
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Bruce M PsatyCardiovascular Health Research Unit, University of Washington, Seattle, WA, 98101, USA.ORCID 0000-0002-7278-2190
Susan RedlineDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, 02115, USA.ORCID 0000-0002-6585-1610
Alan R ShuldinerProgram for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, 21231, USA.
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.ORCID 0000-0002-2756-4370
Ramachandran S VasanNational Heart Lung and Blood Institute and Boston University's Framingham Heart Study, Framingham, MA, 01702, USA.ORCID 0000-0001-7357-5970
Karine A Viaud-MartinezIllumina Laboratory Services, Illumina, Inc, San Diego, CA, 92122, USA.
Jose C FlorezMetabolism Program, The Broad Institute of MIT and Harvard, Cambridge, MA, 02124, USA.
James G WilsonDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, 02115, USA.
Robert SladekDepartment of Human Genetics, McGill University, Montreal, Montreal, Quebec, H3A 0G1, Canada.ORCID 0000-0002-2730-1204
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, 22908, USA.ORCID 0000-0003-3872-7793
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.ORCID 0000-0001-7191-1723
Xihong LinDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Josée DupuisDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.ORCID 0000-0003-2871-3603
James B MeigsDepartment of Medicine, Harvard Medical School, Boston, MA, 02115, USA.
Jennifer WesselDepartment of Epidemiology, Fairbanks School of Public Health, Indiana University, IN, 46202, USA. wesselj@iu.edu.ORCID 0000-0002-7031-0085
Alisa K ManningClinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, 02114, USA. amanning@broadinstitute.org.ORCID 0000-0003-0247-902X

Funding

Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
NHLBI Data Stage Coordinating CenterOT3HL147154 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ashok Kumar Krishnamurthy · 2018 to 2026
$98.9M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
ZINC AND CA EDTA THERAPY OF PLUMBISMM01RR000052 · NCRR · JOHNS HOPKINS UNIVERSITY · PI MARSH, LAURA · 1985 to 2007
$37.3M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8M
PEDIGREE ANALYSIS OF LIPOPROTEIN PHENOTYPESP01HL045522 · NHLBI · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI ALMASY, LAURA A. · 1991 to 2012
$27.6M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Tulane COBRE in Cardiometabolic Diseases Clinical Research CoreP20GM109036 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Ning Liu · 2016 to 2026
$25.3M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
NCATS NIH HHS KL2 TR002490NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NCI NIH HHS R35 CA197449NCRR NIH HHS KL2 RR024990NCRR NIH HHS M01 RR000052NCRR NIH HHS M01 RR016500NCRR NIH HHS UL1 RR033176NHGRI NIH HHS R01 HG010297NHGRI NIH HHS R56 HG010297NHGRI NIH HHS U01 HG004803NHGRI NIH HHS U01 HG007416NHGRI NIH HHS U01 HG009088NHGRI NIH HHS U54 HG003067NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012CNHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014CNHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INHLBI NIH HHS K01 HL130609NHLBI NIH HHS K01 HL135405NHLBI NIH HHS K23 HL105897NHLBI NIH HHS K24 HL148521NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS OT3 HL147154NHLBI NIH HHS P01 HL045522NHLBI NIH HHS R01 HL046380NHLBI NIH HHS R01 HL049762NHLBI NIH HHS R01 HL055673NHLBI NIH HHS R01 HL059684NHLBI NIH HHS R01 HL071025NHLBI NIH HHS R01 HL071051NHLBI NIH HHS R01 HL071205NHLBI NIH HHS R01 HL071250NHLBI NIH HHS R01 HL071251NHLBI NIH HHS R01 HL071258NHLBI NIH HHS R01 HL071259NHLBI NIH HHS R01 HL085571NHLBI NIH HHS R01 HL087263NHLBI NIH HHS R01 HL087660NHLBI NIH HHS R01 HL087698NHLBI NIH HHS R01 HL088119NHLBI NIH HHS R01 HL090682NHLBI NIH HHS R01 HL092165NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL093093NHLBI NIH HHS R01 HL104135NHLBI NIH HHS R01 HL112064NHLBI NIH HHS R01 HL113323NHLBI NIH HHS R01 HL113338NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL119443NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL131136NHLBI NIH HHS R01 HL133040NHLBI NIH HHS R01 HL142825NHLBI NIH HHS R01 HL153805NHLBI NIH HHS R01 HL153814NHLBI NIH HHS R01 HL163560NHLBI NIH HHS R03 HL154284NHLBI NIH HHS R35 HL135818NHLBI NIH HHS RC1 HL099747NHLBI NIH HHS T32 HL007055NHLBI NIH HHS T32 HL129982NHLBI NIH HHS U01 HL054457NHLBI NIH HHS U01 HL054464NHLBI NIH HHS U01 HL054472NHLBI NIH HHS U01 HL054473NHLBI NIH HHS U01 HL054481NHLBI NIH HHS U01 HL054495NHLBI NIH HHS U01 HL054509NHLBI NIH HHS U01 HL072507NHLBI NIH HHS U01 HL072515NHLBI NIH HHS U01 HL072518NHLBI NIH HHS U01 HL072524NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL084756NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NHLBI NIH HHS U01 HL137181NHLBI NIH HHS U10 HL054457NHLBI NIH HHS U10 HL054464NHLBI NIH HHS U10 HL054481NIA NIH HHS K99 AG066849NIA NIH HHS R00 AG066849NIA NIH HHS R01 AG018728NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG058921NIDDK NIH HHS K01 DK107836NIDDK NIH HHS K24 DK110550NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK072488NIDDK NIH HHS P60 DK079637NIDDK NIH HHS R01 DK047482NIDDK NIH HHS R01 DK053889NIDDK NIH HHS R01 DK054261NIDDK NIH HHS R01 DK125403NIDDK NIH HHS U01 DK078616NIDDK NIH HHS U01 DK085524NIDDK NIH HHS U01 DK105554NIDDK NIH HHS UM1 DK078616NIEHS NIH HHS R01 ES029082NIGMS NIH HHS P20 GM109036NIGMS NIH HHS T32 GM074905NIGMS NIH HHS U01 GM074518NIMHD NIH HHS HHSN268201800013INIMH NIH HHS R01 MH078111NIMH NIH HHS R01 MH078143NIMH NIH HHS R01 MH083824NINDS NIH HHS R01 NS062059NINR NIH HHS R01 NR008153
6 · The paper itself

Abstract

The genetic determinants of fasting glucose (FG) and fasting insulin (FI) have been studied mostly through genome arrays, resulting in over 100 associated variants. We extended this work with high-coverage whole genome sequencing analyses from fifteen cohorts in NHLBI's Trans-Omics for Precision Medicine (TOPMed) program. Over 23,000 non-diabetic individuals from five race-ethnicities/populations (African, Asian, European, Hispanic and Samoan) were included. Eight variants were significantly associated with FG or FI across previously identified regions MTNR1B, G6PC2, GCK, GCKR and FOXA2. We additionally characterize suggestive associations with FG or FI near previously identified SLC30A8, TCF7L2, and ADCY5 regions as well as APOB, PTPRT, and ROBO1. Functional annotation resources including the Diabetes Epigenome Atlas were compiled for each signal (chromatin states, annotation principal components, and others) to elucidate variant-to-function hypotheses. We provide a catalog of nucleotide-resolution genomic variation spanning intergenic and intronic regions creating a foundation for future sequencing-based investigations of glycemic traits.

Indexed as

Diabetes Mellitus, Type 2FastingGlucoseHumansInsulinNational Heart, Lung, and Blood Institute (U.S.)Nerve Tissue ProteinsPolymorphism, Single NucleotidePrecision MedicineReceptors, ImmunologicUnited StatesGlucoseInsulinNerve Tissue ProteinsReceptors, Immunologic

Identifiers

PMID35902682
PMCPMC9334637

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.