ArticleNature communications2022
Protein secondary structure in spider silk nanofibrils.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 93 citations in OpenAlex.
- Moderate moisture evaporation strengthens the network structure and practical features of konjac glucomannan/soy protein isolate system during drying process.Food chemistry: X · 2026Article
- pH-triggered clustering regulates β-sheet activation in silk assembly.Communications chemistry · 2026Article
- In situ secondary structure imaging of protein phase separation and aggregation by hyperspectral stimulated Raman scattering microscopy.Nature communications · 2025Article
- Physics-informed deep learning for plasmonic sensing of nanoscale protein dynamics in solution.Science advances · 2025Article
- Electrochemical-Genetic Programming of Protein-Based Magnetic Soft Robots for Active Drug Delivery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Manipulating the Assembly and Architecture of Fibrillar Silk.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Structural Mechanisms of Forced Unfolding of Double-Stranded Fibrin Oligomers.The journal of physical chemistry. B · 2025Article
- Elasticity Anisotropy ofBiomacromolecules · 2025Article
- Engineered Protein Fibers with Reinforced Mechanical Properties Via β-Sheet High-Order Assembly.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Tailoring hydrophobicity and strength in spider silk-inspired coatings via thermal treatments.Computational and structural biotechnology journal · 2024Article
- Progress in Multiscale Modeling of Silk Materials.Biomacromolecules · 2024Review
- Strategies for Making High-Performance Artificial Spider Silk Fibers.Advanced functional materials · 2024Review
- Structural analysis of silk using solid-state NMR.Magnetic resonance letters · 2024Review
- A recombinant chimeric spider pyriform-aciniform silk with highly tunable mechanical performance.Materials today. Bio · 2024Article
- Liquid-Liquid Phase Separation-Mediated Photocatalytic Subcellular Hybrid System for Highly Efficient Hydrogen Production.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- In-situ observation of silk nanofibril assembly via graphene plasmonic infrared sensor.Nature communications · 2024Article
- Regenerated Fiber's Ideal Target: Comparable to Natural Fiber.Materials (Basel, Switzerland) · 2024Review
- Genetically Engineered Protein-Based Bioadhesives with Programmable Material Properties.ACS applied materials & interfaces · 2023Article
- Spidroins under the Influence of Alcohol: Effect of Ethanol on Secondary Structure and Molecular Level Solvation of Silk-Like Proteins.Biomacromolecules · 2023Article
- Nanoscale imaging of major and minor ampullate silk from the orb-web spider Nephila Madagascariensis.Scientific reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanofibrils play a pivotal role in spider silk and are responsible for many of the impressive properties of this unique natural material. However, little is known about the internal structure of these protein fibrils. We carry out polarized Raman and polarized Fourier-transform infrared spectroscopies on native spider silk nanofibrils and determine the concentrations of six distinct protein secondary structures, including β-sheets, and two types of helical structures, for which we also determine orientation distributions. Our advancements in peak assignments are in full agreement with the published silk vibrational spectroscopy literature. We further corroborate our findings with X-ray diffraction and magic-angle spinning nuclear magnetic resonance experiments. Based on the latter and on polypeptide Raman spectra, we assess the role of key amino acids in different secondary structures. For the recluse spider we develop a highly detailed structural model, featuring seven levels of structural hierarchy. The approaches we develop are directly applicable to other proteinaceous materials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.