Evidence map›Paper›PMID 35902567›Full record

ArticleSignal transduction and targeted therapy2022

Cardiomyocytes induced from hiPSCs by well-defined compounds have therapeutic potential in heart failure by secreting PDGF-BB.

Hongmei Li, Fenfang Wu, Guangrui Huang, Di Wu, Ting Wang, Xiashuang Wang, Kai Wang, Yuyin Feng, Anlong Xu

Open access · goldAbstract read
In one paragraph

Article in Signal transduction and targeted therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Hongmei LiSchool of Life Science, Beijing University of Chinese Medicine, Beijing, China.
Fenfang WuShenzhen Hospital, Beijing University of Chinese Medicine, Shenzhen, China.
Guangrui HuangSchool of Life Science, Beijing University of Chinese Medicine, Beijing, China.
Di WuCollege of Life Sciences, Sun Yat-Sen University, Guangzhou, China.
Ting WangSchool of Life Science, Beijing University of Chinese Medicine, Beijing, China.
Xiashuang WangCollege of Life Sciences, Sun Yat-Sen University, Guangzhou, China.
Kai WangDongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Yuyin FengSchool of Life Science, Beijing University of Chinese Medicine, Beijing, China.
Anlong XuSchool of Life Science, Beijing University of Chinese Medicine, Beijing, China. xuanlong@bucm.edu.cn.
Beijing University of Chinese Medicine · CNSun Yat-sen University · CNDongzhimen Hospital Affiliated to Beijing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies have suggested that transplant of hiPS-CMs is a promising approach for treating heart failure. However, the optimally clinical benefits have been hampered by the immature nature of the hiPS-CMs, and the hiPS-CMs-secreted proteins contributing to the repair of cardiomyocytes remain largely unidentified. Here, we established a saponin

Indexed as

Heart FailureMyocytes, CardiacAnimalsBecaplerminHumansInduced Pluripotent Stem CellsMicePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktVentricular RemodelingBecaplerminPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-akt

Identifiers

PMID35902567
PMCPMC9334380
OpenAlexW4288425105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.