ArticleCanadian journal of anaesthesia = Journal canadien d'anesthesie2022
White blood cell count trajectory and mortality in septic shock: a historical cohort study.
Article in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 35 citations in OpenAlex.
- Clinical course of patients with bloodstream infections enrolled in the BALANCE clinical trial.The Journal of antimicrobial chemotherapy · 2025Trial
- Validation of SOFA-2 score in sepsis and exploration of its extension with additional immune markers.Journal of intensive medicine · 2026Article
- A Simple Admission-Based Score for Early Mortality Risk Stratification in Non-Shock Sepsis: A Pilot Study.Diagnostics (Basel, Switzerland) · 2026Article
- Risk Factors for Mortality in Patients With Strangulating Intestinal Obstruction Who Present With Septic Disseminated Intravascular Coagulation Prior to the Initiation of Treatment.Gastroenterology research · 2026Article
- Systematic review, meta-analysis, and meta-regression of the association of serial leukocyte counts in critically ill patients and mortality.Annals of intensive care · 2026Article
- Isolated Rectal Wall Necrosis Presenting with Septic Shock: A Rare Manifestation of Non-Occlusive Ischaemia.European journal of case reports in internal medicine · 2026Article
- Construction of a Risk Prediction Model for Stroke Occurrence in Septic Shock Patients: A Combined Analysis Using LASSO and Multivariate Logistic Regression.International journal of general medicine · 2026Article
- The Impact of White Blood Cell Count Trajectories on Prognosis and Secondary Acute Kidney Injury in Sepsis Patients.Mediators of inflammation · 2026Article
- Hemoperfusion with a polymer-based column alters inflammatory responses in lipopolysaccharide-treated horses in vivo.American journal of veterinary research · 2025Article
- Early Diagnostic Markers and Risk Stratification in Sepsis: Prognostic Value of Neutrophil-to-Lymphocyte Ratio, Platelets, and the Carmeli Score.Biomedicines · 2025Article
- Prognostic Value of Inflammatory Markers in Septic Critically Ill Patients with Chronic Liver Disease: A Retrospective Analysis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025Article
- FedWeight: mitigating covariate shift of federated learning on electronic health records data through patients re-weighting.NPJ digital medicine · 2025Article
- Clinical subtypes identification and feature recognition of sepsis leukocyte trajectories based on machine learning.Scientific reports · 2025Article
- A study on the correlation between albumin-to-alkaline phosphatase ratio and the severity of pelvic inflammatory disease.Frontiers in medicine · 2025Article
- Complement activation and humoral immune dysregulation drive progression of pediatric septic shock: a retrospective cohort study.American journal of translational research · 2025Article
- Development and validation of web-based, interpretable predictive models for sepsis and mortality in extensive burns.Frontiers in cellular and infection microbiology · 2025Article
- Independent and combined associations of high-density lipoprotein cholesterol-modified triglyceride-glucose index with all-cause and cardiovascular mortality in patients with acute decompensated heart failure.Frontiers in endocrinology · 2025Article
- Comparison of CytoSorb and Jafron HA330 Hemoadsorption Devices in Pediatric Oncological Patients with Sepsis: Retrospective Observational Study.Journal of clinical medicine · 2024Article
- Constructing a nomogram for the recurrence of tibial osteomyelitis after debridement surgery based on platelet to lymphocyte ratio at admission: a dual-center retrospective study from China.BMC musculoskeletal disorders · 2024Article
- Correlation of HCT-ALB, SmtO2, CRT and LAC with renal impairment and prognosis in patients with septic shock.Journal of medical biochemistry · 2024Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSeptic shock is associated with a mortality of 20-40%. The white blood cell count (WBC) at hospital admission correlates with prognosis in septic shock. Here, we explore whether the trajectory of WBC after admission provides further information about outcomes. We aimed to identify groups of patients with different WBC trajectories and the association of WBC trajectory with mortality.
methodsWe included adult patients with septic shock in two academic intensive care units (ICU) in Winnipeg, MB, Canada between 2006 and 2012. We used group-based trajectory analysis to group patients according to their WBC patterns over the first seven days in the ICU. Our primary analysis was the association of WBC trajectory group on 30-day mortality using multivariable Cox proportional hazards regression.
resultsWe included 917 patients with septic shock. The final model identified seven distinct WBC trajectories. The rising WBC trajectory was independently associated with increased mortality (hazard ratio, 3.41; 95% confidence interval, 1.86 to 6.26; P < 0.001) compared with the stable WBC trajectory.
conclusionIn patients with septic shock, distinct and clinically relevant groups can be identified by analyzing WBC trajectories. A rising WBC trajectory was associated with higher mortality.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.