Evidence map›Paper›PMID 35902212›Full record

ArticleJournal of occupational and environmental medicine2022

Cross-sectional Study of Workers Employed at a Copper Smelter-Effects of Long-term Exposures to Copper on Lung Function and Chronic Inflammation.

Lisa-Marie Haase, Thomas Birk, Craig A Poland, Olaf Holz, Meike Müller, Annette M Bachand, Kenneth A Mundt

Open access · hybridAbstract read
In one paragraph

Article in Journal of occupational and environmental medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Lisa-Marie HaaseFrom the Ramboll Deutschland GmbH, Essen, Germany (Ms Haase, Mr Birk); Regulatory Compliance Limited, Loanhead, Edinburgh (Dr Poland); Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK (Dr Poland); Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany (Dr Holz, Dr Müller); German Center for Lung Research (DZL, BREATH), Hannover, Germany (Dr Holz); Ramboll US Consulting, Inc, Amherst, Massachusetts (Dr Bachand); Cardno ChemRisk, Boston, Massachusetts (Dr Mundt).
Thomas Birk
Craig A Poland
Olaf Holz
Meike Müller
Annette M Bachand
Kenneth A Mundt
Birkbeck, University of London · GBFraunhofer Institute for Toxicology and Experimental Medicine · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of the study was to assess the effect of exposure to copper-containing dust on lung function and inflammatory endpoints among workers of a German copper plant, effects rarely studied before.

methodsOne hundred four copper-exposed smelter workers and 70 referent workers from the precious metal and lead facilities were included, with different metal exposures in both groups due to the different process materials. Body plethysmography, exhaled nitric oxide (FeNO) measurements, and blood sampling were conducted in all workers. Smoking status and the use of respiratory protective equipment were considered. In a subgroup of 40 nonsmoking volunteers (28 copper-exposed and 12 referents), sputum biomarkers were assessed.

resultsMedian lung function values of both copper-exposed and the referent groups were within reference ranges of "healthy" individuals, and statistical differences between the groups were mostly not evident. Similarly, differences in blood and sputum biomarkers were too small to be biologically relevant.

conclusionThe results suggest the absence of the detectable effects of copper-containing dust exposure on lung function or chronic inflammation within the investigated cohort.

Indexed as

CopperOccupational ExposureBiomarkersCross-Sectional StudiesDustHumansInflammationLungBiomarkersCopperDust

Identifiers

PMID35902212
PMCPMC9426729
OpenAlexW4288727718

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.