Evidence map›Paper›PMID 35902131›Full record

ArticleJournal for immunotherapy of cancer2022

Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of nonmelanoma skin cancer.

Ann W Silk, Christopher A Barker, Shailender Bhatia, Kathryn B Bollin, Sunandana Chandra, Zeynep Eroglu, Brian R Gastman, Kari L Kendra, Harriet Kluger, Evan J Lipson and 11 more

Open access · goldAbstract read
In one paragraph

Article in Journal for immunotherapy of cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  9. Article
  10. Review
  11. Review
  12. Access to systemic treatment of non-melanoma skin cancer in Spain: a survey analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article
  13. Review
  14. Merkel Cell Carcinoma.Hematology/oncology clinics of North America · 2024
    Review
  15. Review
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 19 institutions in 1 country.

Ann W SilkMerkel Cell Carcinoma Center of Excellence, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA ann_silk@dfci.harvard.edu isaac.brownell@nih.gov.ORCID 0000-0003-3877-3984
Christopher A BarkerDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Shailender BhatiaDivision of Medical Oncology, Department of Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-3816-2238
Kathryn B BollinHematology and Medical Oncology, Scripps MD Anderson Cancer Center, San Diego, California, USA.
Sunandana ChandraHematology Oncology Division, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Zeynep ErogluDepartment of Cutaneous Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.ORCID 0000-0002-2307-7030
Brian R GastmanMelanoma and High-Risk Skin Cancer Program, Cleveland Clinic Cancer Center, Cleveland, Ohio, USA.
Kari L KendraDivision Of Medical Oncology, The Ohio State University, Columbus, Ohio, USA.
Harriet KlugerYale Cancer Center, Yale University, New Haven, Connecticut, USA.
Evan J LipsonBloomberg Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-2976-0911
Kathleen MaddenMelanoma/Cutaneous Oncology Program, New York University Langone Perlmutter Cancer Center, New York, New York, USA.
David M MillerDepartment of Medicine and Department of Dermatology, Massachusetts General Cancer Center, Boston, Massachusetts, USA.ORCID 0000-0001-9736-9119
Paul NghiemDivision of Dermatology, Department of Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-2784-963X
Anna C PavlickDivision of Hematology and Medical Oncology, Weill Cornell Medicine, New York, New York, USA.
Igor PuzanovDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.ORCID 0000-0002-9803-3497
Guilherme RabinowitsDepartment of Hematology/Oncology, Miami Cancer Institute/Baptist Health South Florida, Miami, Florida, USA.
Emily S RuizMohs and Dermatologic Surgery Center, Dana-Farber/Brigham and Women's Hospital, Boston, Massachusetts, USA.
Vernon K SondakDepartment of Cutaneous Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
Edward A TavssIndependent Contributor, New Brunswick, New Jersey, USA.
Michael T TetzlaffDermopathology Division, University of California San Francisco, San Francisco, California, USA.
Isaac BrownellDermatology Branch, National Institutes of Health, Bethesda, Maryland, USA ann_silk@dfci.harvard.edu isaac.brownell@nih.gov.ORCID 0000-0002-0090-9914
Moffitt Cancer Center · USBaptist Hospital of Miami · USBloomberg (United States) · USBrigham and Women's Hospital · USCleveland Clinic · USCornell University · USDana-Farber Cancer Institute · USMassachusetts General Hospital · USMemorial Sloan Kettering Cancer Center · USNational Institutes of Health · USNorthwestern University · USNYU Langone Health · USRoswell Park Comprehensive Cancer Center · USScripps MD Anderson Cancer Center · USThe Ohio State University · USUniversity of California, San Francisco · USUniversity of Washington · USUniversity of Washington Medical Center · USYale Cancer Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Understand & overcome resistance to PD-1P01CA225517 · NCI · UNIVERSITY OF WASHINGTON · PI Cecilia C Yeung · 2019 to 2026
$22.7M
Clinical treatment of advanced Merkel cell carcinomaZIAAR041223 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI BROWNELL, ISAAC · 2022 to 2025
$2.0M
Investigation of skin cancer and skin diseaseZIAAR041224 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI BROWNELL, ISAAC · 2022 to 2025
$1.0M
NCATS NIH HHS UL1 TR001863NCI NIH HHS P01 CA225517
6 · The paper itself

Abstract

Nonmelanoma skin cancers (NMSCs) are some of the most commonly diagnosed malignancies. In general, early-stage NMSCs have favorable outcomes; however, a small subset of patients develop resistant, advanced, or metastatic disease, or aggressive subtypes that are more challenging to treat successfully. Recently, immune checkpoint inhibitors (ICIs) have been approved by the US Food and Drug Administration (FDA) for the treatment of Merkel cell carcinoma (MCC), cutaneous squamous cell carcinoma (CSCC), and basal cell carcinoma (BCC). Although ICIs have demonstrated activity against NMSCs, the routine clinical use of these agents may be more challenging due to a number of factors including the lack of predictive biomarkers, the need to consider special patient populations, the management of toxicity, and the assessment of atypical responses. With the goal of improving patient care by providing expert guidance to the oncology community, the Society for Immunotherapy of Cancer (SITC) convened a multidisciplinary panel of experts to develop a clinical practice guideline (CPG). The expert panel drew on the published literature as well as their own clinical experience to develop recommendations for healthcare professionals on important aspects of immunotherapeutic treatment for NMSCs, including staging, biomarker testing, patient selection, therapy selection, post-treatment response evaluation and surveillance, and patient quality of life (QOL) considerations, among others. The evidence- and consensus-based recommendations in this CPG are intended to provide guidance to cancer care professionals treating patients with NMSCs.

Indexed as

Basal Cell CarcinomaCarcinoma, Squamous CellImmunotherapySkin NeoplasmsClinical Trials as TopicGuidelines as TopicHumansQuality of Lifeclinical trials as topicguidelines as topicimmunotherapyskin neoplasms

Identifiers

PMID35902131
PMCPMC9341183
OpenAlexW4288456936

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.