Evidence map›Paper›PMID 35902105›Full record

ArticleCanadian journal of surgery. Journal canadien de chirurgie

Premortem anticoagulation timing and dose in donation after circulatory death: multicentre study of associations with graft function.

Andreas H Kramer, Kerry Holliday, Sean Keenan, George Isac, Demetrius J Kutsogiannis, Norman M Kneteman, Peter Kim, Adrian Robertson, Peter W Nickerson, Lee Anne Tibbles

Open access · diamondAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of surgery. Journal canadien de chirurgie. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Renal Vein Thrombosis: A Narrative Review.Diagnostics (Basel, Switzerland) · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Andreas H KramerFrom the Department of Critical Care Medicine, University of Calgary, Calgary, Alta. (Kramer); the Department of Clinical Neurosciences, University of Calgary, Calgary, Alta. (Kramer); the Southern Alberta Organ and Tissue Donation Program, Calgary, Alta. (Kramer); the Specialist in End-of-Life Care, Neuroprognostication and Donation (SEND) Program, Alberta Health Services (Holliday); the Division of Critical Care Medicine, Department of Medicine, University of British Columbia, Vancouver, B.C. (Keenan, Isac); BC Transplant, Vancouver, B.C. (Keenan, Isac); the Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alta. (Kutsogiannis); the Human Organ Procurement and Exchange Program, Alberta Transplant Institute, University of Alberta, Edmonton, Alta. (Kutsogiannis); the Department of Surgery, University of Alberta, Edmonton, Alta. (Kneteman); the Alberta Transplant Institute, University of Alberta, Edmonton, Alta. (Kneteman, Tibbles); the Department of Surgery, University of British Columbia, Vancouver, B.C. (Kim); the Section of Critical Care Medicine, Department of Medicine, University of Manitoba, Winnipeg, Man. (Robertson); Transplant Manitoba, Winnipeg, Man. (Robertson, Nickerson); the Section of Nephrology, Department of Medicine, University of Manitoba, Winnipeg, Man. (Nickerson); the Southern Alberta Transplant Program, Calgary, Alta. (Tibbles); and the Division of Nephrology, Department of Medicine, University of Calgary, Calgary, Alta. (Tibbles) andreas.kramer@albertahealthservices.ca.
Kerry HollidayFrom the Department of Critical Care Medicine, University of Calgary, Calgary, Alta. (Kramer); the Department of Clinical Neurosciences, University of Calgary, Calgary, Alta. (Kramer); the Southern Alberta Organ and Tissue Donation Program, Calgary, Alta. (Kramer); the Specialist in End-of-Life Care, Neuroprognostication and Donation (SEND) Program, Alberta Health Services (Holliday); the Division of Critical Care Medicine, Department of Medicine, University of British Columbia, Vancouver, B.C. (Keenan, Isac); BC Transplant, Vancouver, B.C. (Keenan, Isac); the Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alta. (Kutsogiannis); the Human Organ Procurement and Exchange Program, Alberta Transplant Institute, University of Alberta, Edmonton, Alta. (Kutsogiannis); the Department of Surgery, University of Alberta, Edmonton, Alta. (Kneteman); the Alberta Transplant Institute, University of Alberta, Edmonton, Alta. (Kneteman, Tibbles); the Department of Surgery, University of British Columbia, Vancouver, B.C. (Kim); the Section of Critical Care Medicine, Department of Medicine, University of Manitoba, Winnipeg, Man. (Robertson); Transplant Manitoba, Winnipeg, Man. (Robertson, Nickerson); the Section of Nephrology, Department of Medicine, University of Manitoba, Winnipeg, Man. (Nickerson); the Southern Alberta Transplant Program, Calgary, Alta. (Tibbles); and the Division of Nephrology, Department of Medicine, University of Calgary, Calgary, Alta. (Tibbles).
Sean KeenanFrom the Department of Critical Care Medicine, University of Calgary, Calgary, Alta. (Kramer); the Department of Clinical Neurosciences, University of Calgary, Calgary, Alta. (Kramer); the Southern Alberta Organ and Tissue Donation Program, Calgary, Alta. (Kramer); the Specialist in End-of-Life Care, Neuroprognostication and Donation (SEND) Program, Alberta Health Services (Holliday); the Division of Critical Care Medicine, Department of Medicine, University of British Columbia, Vancouver, B.C. (Keenan, Isac); BC Transplant, Vancouver, B.C. (Keenan, Isac); the Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alta. (Kutsogiannis); the Human Organ Procurement and Exchange Program, Alberta Transplant Institute, University of Alberta, Edmonton, Alta. (Kutsogiannis); the Department of Surgery, University of Alberta, Edmonton, Alta. (Kneteman); the Alberta Transplant Institute, University of Alberta, Edmonton, Alta. (Kneteman, Tibbles); the Department of Surgery, University of British Columbia, Vancouver, B.C. (Kim); the Section of Critical Care Medicine, Department of Medicine, University of Manitoba, Winnipeg, Man. (Robertson); Transplant Manitoba, Winnipeg, Man. (Robertson, Nickerson); the Section of Nephrology, Department of Medicine, University of Manitoba, Winnipeg, Man. (Nickerson); the Southern Alberta Transplant Program, Calgary, Alta. (Tibbles); and the Division of Nephrology, Department of Medicine, University of Calgary, Calgary, Alta. (Tibbles).
George IsacFrom the Department of Critical Care Medicine, University of Calgary, Calgary, Alta. (Kramer); the Department of Clinical Neurosciences, University of Calgary, Calgary, Alta. (Kramer); the Southern Alberta Organ and Tissue Donation Program, Calgary, Alta. (Kramer); the Specialist in End-of-Life Care, Neuroprognostication and Donation (SEND) Program, Alberta Health Services (Holliday); the Division of Critical Care Medicine, Department of Medicine, University of British Columbia, Vancouver, B.C. (Keenan, Isac); BC Transplant, Vancouver, B.C. (Keenan, Isac); the Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alta. (Kutsogiannis); the Human Organ Procurement and Exchange Program, Alberta Transplant Institute, University of Alberta, Edmonton, Alta. (Kutsogiannis); the Department of Surgery, University of Alberta, Edmonton, Alta. (Kneteman); the Alberta Transplant Institute, University of Alberta, Edmonton, Alta. (Kneteman, Tibbles); the Department of Surgery, University of British Columbia, Vancouver, B.C. (Kim); the Section of Critical Care Medicine, Department of Medicine, University of Manitoba, Winnipeg, Man. (Robertson); Transplant Manitoba, Winnipeg, Man. (Robertson, Nickerson); the Section of Nephrology, Department of Medicine, University of Manitoba, Winnipeg, Man. (Nickerson); the Southern Alberta Transplant Program, Calgary, Alta. (Tibbles); and the Division of Nephrology, Department of Medicine, University of Calgary, Calgary, Alta. (Tibbles).
Demetrius J KutsogiannisFrom the Department of Critical Care Medicine, University of Calgary, Calgary, Alta. (Kramer); the Department of Clinical Neurosciences, University of Calgary, Calgary, Alta. (Kramer); the Southern Alberta Organ and Tissue Donation Program, Calgary, Alta. (Kramer); the Specialist in End-of-Life Care, Neuroprognostication and Donation (SEND) Program, Alberta Health Services (Holliday); the Division of Critical Care Medicine, Department of Medicine, University of British Columbia, Vancouver, B.C. (Keenan, Isac); BC Transplant, Vancouver, B.C. (Keenan, Isac); the Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alta. (Kutsogiannis); the Human Organ Procurement and Exchange Program, Alberta Transplant Institute, University of Alberta, Edmonton, Alta. (Kutsogiannis); the Department of Surgery, University of Alberta, Edmonton, Alta. (Kneteman); the Alberta Transplant Institute, University of Alberta, Edmonton, Alta. (Kneteman, Tibbles); the Department of Surgery, University of British Columbia, Vancouver, B.C. (Kim); the Section of Critical Care Medicine, Department of Medicine, University of Manitoba, Winnipeg, Man. (Robertson); Transplant Manitoba, Winnipeg, Man. (Robertson, Nickerson); the Section of Nephrology, Department of Medicine, University of Manitoba, Winnipeg, Man. (Nickerson); the Southern Alberta Transplant Program, Calgary, Alta. (Tibbles); and the Division of Nephrology, Department of Medicine, University of Calgary, Calgary, Alta. (Tibbles).
Norman M KnetemanFrom the Department of Critical Care Medicine, University of Calgary, Calgary, Alta. (Kramer); the Department of Clinical Neurosciences, University of Calgary, Calgary, Alta. (Kramer); the Southern Alberta Organ and Tissue Donation Program, Calgary, Alta. (Kramer); the Specialist in End-of-Life Care, Neuroprognostication and Donation (SEND) Program, Alberta Health Services (Holliday); the Division of Critical Care Medicine, Department of Medicine, University of British Columbia, Vancouver, B.C. (Keenan, Isac); BC Transplant, Vancouver, B.C. (Keenan, Isac); the Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alta. (Kutsogiannis); the Human Organ Procurement and Exchange Program, Alberta Transplant Institute, University of Alberta, Edmonton, Alta. (Kutsogiannis); the Department of Surgery, University of Alberta, Edmonton, Alta. (Kneteman); the Alberta Transplant Institute, University of Alberta, Edmonton, Alta. (Kneteman, Tibbles); the Department of Surgery, University of British Columbia, Vancouver, B.C. (Kim); the Section of Critical Care Medicine, Department of Medicine, University of Manitoba, Winnipeg, Man. (Robertson); Transplant Manitoba, Winnipeg, Man. (Robertson, Nickerson); the Section of Nephrology, Department of Medicine, University of Manitoba, Winnipeg, Man. (Nickerson); the Southern Alberta Transplant Program, Calgary, Alta. (Tibbles); and the Division of Nephrology, Department of Medicine, University of Calgary, Calgary, Alta. (Tibbles).
Peter KimFrom the Department of Critical Care Medicine, University of Calgary, Calgary, Alta. (Kramer); the Department of Clinical Neurosciences, University of Calgary, Calgary, Alta. (Kramer); the Southern Alberta Organ and Tissue Donation Program, Calgary, Alta. (Kramer); the Specialist in End-of-Life Care, Neuroprognostication and Donation (SEND) Program, Alberta Health Services (Holliday); the Division of Critical Care Medicine, Department of Medicine, University of British Columbia, Vancouver, B.C. (Keenan, Isac); BC Transplant, Vancouver, B.C. (Keenan, Isac); the Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alta. (Kutsogiannis); the Human Organ Procurement and Exchange Program, Alberta Transplant Institute, University of Alberta, Edmonton, Alta. (Kutsogiannis); the Department of Surgery, University of Alberta, Edmonton, Alta. (Kneteman); the Alberta Transplant Institute, University of Alberta, Edmonton, Alta. (Kneteman, Tibbles); the Department of Surgery, University of British Columbia, Vancouver, B.C. (Kim); the Section of Critical Care Medicine, Department of Medicine, University of Manitoba, Winnipeg, Man. (Robertson); Transplant Manitoba, Winnipeg, Man. (Robertson, Nickerson); the Section of Nephrology, Department of Medicine, University of Manitoba, Winnipeg, Man. (Nickerson); the Southern Alberta Transplant Program, Calgary, Alta. (Tibbles); and the Division of Nephrology, Department of Medicine, University of Calgary, Calgary, Alta. (Tibbles).
Adrian RobertsonFrom the Department of Critical Care Medicine, University of Calgary, Calgary, Alta. (Kramer); the Department of Clinical Neurosciences, University of Calgary, Calgary, Alta. (Kramer); the Southern Alberta Organ and Tissue Donation Program, Calgary, Alta. (Kramer); the Specialist in End-of-Life Care, Neuroprognostication and Donation (SEND) Program, Alberta Health Services (Holliday); the Division of Critical Care Medicine, Department of Medicine, University of British Columbia, Vancouver, B.C. (Keenan, Isac); BC Transplant, Vancouver, B.C. (Keenan, Isac); the Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alta. (Kutsogiannis); the Human Organ Procurement and Exchange Program, Alberta Transplant Institute, University of Alberta, Edmonton, Alta. (Kutsogiannis); the Department of Surgery, University of Alberta, Edmonton, Alta. (Kneteman); the Alberta Transplant Institute, University of Alberta, Edmonton, Alta. (Kneteman, Tibbles); the Department of Surgery, University of British Columbia, Vancouver, B.C. (Kim); the Section of Critical Care Medicine, Department of Medicine, University of Manitoba, Winnipeg, Man. (Robertson); Transplant Manitoba, Winnipeg, Man. (Robertson, Nickerson); the Section of Nephrology, Department of Medicine, University of Manitoba, Winnipeg, Man. (Nickerson); the Southern Alberta Transplant Program, Calgary, Alta. (Tibbles); and the Division of Nephrology, Department of Medicine, University of Calgary, Calgary, Alta. (Tibbles).
Peter W NickersonFrom the Department of Critical Care Medicine, University of Calgary, Calgary, Alta. (Kramer); the Department of Clinical Neurosciences, University of Calgary, Calgary, Alta. (Kramer); the Southern Alberta Organ and Tissue Donation Program, Calgary, Alta. (Kramer); the Specialist in End-of-Life Care, Neuroprognostication and Donation (SEND) Program, Alberta Health Services (Holliday); the Division of Critical Care Medicine, Department of Medicine, University of British Columbia, Vancouver, B.C. (Keenan, Isac); BC Transplant, Vancouver, B.C. (Keenan, Isac); the Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alta. (Kutsogiannis); the Human Organ Procurement and Exchange Program, Alberta Transplant Institute, University of Alberta, Edmonton, Alta. (Kutsogiannis); the Department of Surgery, University of Alberta, Edmonton, Alta. (Kneteman); the Alberta Transplant Institute, University of Alberta, Edmonton, Alta. (Kneteman, Tibbles); the Department of Surgery, University of British Columbia, Vancouver, B.C. (Kim); the Section of Critical Care Medicine, Department of Medicine, University of Manitoba, Winnipeg, Man. (Robertson); Transplant Manitoba, Winnipeg, Man. (Robertson, Nickerson); the Section of Nephrology, Department of Medicine, University of Manitoba, Winnipeg, Man. (Nickerson); the Southern Alberta Transplant Program, Calgary, Alta. (Tibbles); and the Division of Nephrology, Department of Medicine, University of Calgary, Calgary, Alta. (Tibbles).
Lee Anne TibblesFrom the Department of Critical Care Medicine, University of Calgary, Calgary, Alta. (Kramer); the Department of Clinical Neurosciences, University of Calgary, Calgary, Alta. (Kramer); the Southern Alberta Organ and Tissue Donation Program, Calgary, Alta. (Kramer); the Specialist in End-of-Life Care, Neuroprognostication and Donation (SEND) Program, Alberta Health Services (Holliday); the Division of Critical Care Medicine, Department of Medicine, University of British Columbia, Vancouver, B.C. (Keenan, Isac); BC Transplant, Vancouver, B.C. (Keenan, Isac); the Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alta. (Kutsogiannis); the Human Organ Procurement and Exchange Program, Alberta Transplant Institute, University of Alberta, Edmonton, Alta. (Kutsogiannis); the Department of Surgery, University of Alberta, Edmonton, Alta. (Kneteman); the Alberta Transplant Institute, University of Alberta, Edmonton, Alta. (Kneteman, Tibbles); the Department of Surgery, University of British Columbia, Vancouver, B.C. (Kim); the Section of Critical Care Medicine, Department of Medicine, University of Manitoba, Winnipeg, Man. (Robertson); Transplant Manitoba, Winnipeg, Man. (Robertson, Nickerson); the Section of Nephrology, Department of Medicine, University of Manitoba, Winnipeg, Man. (Nickerson); the Southern Alberta Transplant Program, Calgary, Alta. (Tibbles); and the Division of Nephrology, Department of Medicine, University of Calgary, Calgary, Alta. (Tibbles).
University of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn controlled donation after circulatory determination of death (DCD), it is common to administer premortem heparin to potential donors. This practice remains controversial because there is limited evidence for it and there is the possibility of inducing hemorrhage. To our knowledge, no previous studies have assessed the effects of heparin timing and dose on graft function.

methodsWe performed a multicentre cohort study of consecutive DCD donors and the recipients of their organs. Anticoagulation administration was considered early if given near the time of withdrawal of life-sustaining measures and late if delayed until the onset of donor hypoxemia (oxygen saturation < 70%) or hypotension (systolic blood pressure < 60 mm Hg or mean blood pressure < 50 mm Hg). The anticoagulation dose was considered high if it was 300 units/kg or greater.

resultsDonor anticoagulation data were available for 301 kidney, 75 liver and 46 lung recipients. Heparin was administered in 92% of cases and was most commonly withheld in donors with cerebrovascular causes of death (

conclusionPremortem heparin is widely used in DCD cases, but there is variability in timing and dose, which was not associated with kidney outcomes in this study. Donor anticoagulation may have a greater impact in preventing biliary complications following liver transplantation.

Indexed as

Tissue and Organ ProcurementAnticoagulantsBrain DeathCohort StudiesDeathHeparinHumansRetrospective StudiesTissue DonorsAnticoagulantsHeparin

Identifiers

PMID35902105
PMCPMC9343016
OpenAlexW4288426659

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.