Evidence map›Paper›PMID 35902104›Full record

ArticleCanadian journal of surgery. Journal canadien de chirurgie

Intraoperative parathormone monitoring to predict operative success in patients with normohormonal hyperparathyroidism.

Heather Stuart, Basem Azab, Omar Picado Roque, Janice Pasieka, John I Lew

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of surgery. Journal canadien de chirurgie. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Heather StuartFrom the Division of Surgical Oncology, DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, Fla. (Stuart, Azab); the Division of Surgical Oncology, Department of Surgery, University of British Columbia, Vancouver, BC (Stuart); the Division of Endocrine Surgery, DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, Fla. (Picado Roque, Lew); and the Division of Surgical Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alta. (Pasieka) heather.stuart@vch.ca.
Basem AzabFrom the Division of Surgical Oncology, DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, Fla. (Stuart, Azab); the Division of Surgical Oncology, Department of Surgery, University of British Columbia, Vancouver, BC (Stuart); the Division of Endocrine Surgery, DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, Fla. (Picado Roque, Lew); and the Division of Surgical Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alta. (Pasieka).
Omar Picado RoqueFrom the Division of Surgical Oncology, DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, Fla. (Stuart, Azab); the Division of Surgical Oncology, Department of Surgery, University of British Columbia, Vancouver, BC (Stuart); the Division of Endocrine Surgery, DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, Fla. (Picado Roque, Lew); and the Division of Surgical Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alta. (Pasieka).
Janice PasiekaFrom the Division of Surgical Oncology, DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, Fla. (Stuart, Azab); the Division of Surgical Oncology, Department of Surgery, University of British Columbia, Vancouver, BC (Stuart); the Division of Endocrine Surgery, DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, Fla. (Picado Roque, Lew); and the Division of Surgical Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alta. (Pasieka).
John I LewFrom the Division of Surgical Oncology, DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, Fla. (Stuart, Azab); the Division of Surgical Oncology, Department of Surgery, University of British Columbia, Vancouver, BC (Stuart); the Division of Endocrine Surgery, DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, Fla. (Picado Roque, Lew); and the Division of Surgical Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alta. (Pasieka).
University of Miami · USUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is unclear whether parathyroidectomy guided by intraoperative parathormone (PTH) monitoring is predictive of operative success in patients with normohormonal hyperparathyroidism (nhHPT), a variant of primary hyperparathyroidism (pHPT) in which patients develop clinical manifestations similar to those of pHPT. This study examined intraoperative PTH monitoring in patients undergoing parathyroidectomy for nhHPT.

methodsWe performed a retrospective review of prospectively collected data from adult (age > 18 yr) patients who underwent parathyroidectomy for pHPT at 1 of 2 North American medical centres (in Calgary, Alberta, Canada, or Miami, Florida, United States) between 2007 and 2015. In patients with nhHPT, we used the criterion of an intraoperative decrease of more than 50% in PTH after abnormal gland excision. We defined operative success as continuous eucalcemia more than 6 months after parathyroidectomy.

resultsOf 333 patients, 38 (11.4%) had nhHPT, with mean preoperative calcium and PTH levels of 2.7 mmol/L and 53 pg/dL, respectively. An intraoperative decrease of more than 50% in PTH level was seen in 27 patients (71.0%) with nhHPT and 265 patients (89.8%) with classic pHPT at 5 minutes (

conclusionParathyroidectomy guided by intraoperative PTH monitoring accurately predicted operative success in patients with nhHPT. Intraoperative PTH monitoring may also help identify multiglandular disease in patients with nhHPT, using criteria similar to those in classic pHPT, with comparable operative success.

Indexed as

Hyperparathyroidism, PrimaryParathyroid HormoneAdultAlbertaHumansParathyroidectomyRetrospective StudiesParathyroid Hormone

Identifiers

PMID35902104
PMCPMC9343013
OpenAlexW4288443590

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.