ArticleGigaScience2022
Meta-Prism 2.0: Enabling algorithm and web server for ultra-fast, memory-efficient, and accurate analysis among millions of microbial community samples.
Article in GigaScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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Authors and funding
3 authors.
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Abstract
backgroundMicrobial community samples have been accumulating at a speed faster than ever, with hundreds of thousands of samples been sequenced each year. Mining such a huge amount of multisource heterogeneous data is becoming an increasingly difficult challenge, so efficient and accurate compare and search of samples is in urgent need: faced with millions of samples in the data repository, traditional sample comparison and search approaches fall short in speed and accuracy.
findingsHere we proposed Meta-Prism 2.0, a microbial community sample analysis method that has pushed the time and memory efficiency to a new limit without compromising accuracy. Based on sparse data structure, time-saving instruction pipeline, and SIMD optimization, Meta-Prism 2.0 has enabled ultra-fast, memory-efficient, flexible, and accurate search among millions of samples. Meta-Prism 2.0 was put to test on several data sets, with the largest containing 1 million samples. Results show that Meta-Prism 2.0's 0.00001-s per sample pair compare speed and 8-GB memory needs for searching against 1 million samples have made it one of the most efficient sample analysis methods. Additionally, Meta-Prism 2.0 can achieve accuracy comparable with or better than other contemporary methods. Third, Meta-Prism 2.0 can precisely identify the original biome for samples, thus enabling sample source tracking. Finally, we have provided a web server for fast search of microbial community samples online.
conclusionsIn summary, Meta-Prism 2.0 has changed the resource-intensive sample search scheme to an effective procedure, which could be conducted by researchers every day even on a laptop, for insightful sample search, similarity analysis, and knowledge discovery. Meta-Prism 2.0 can be accessed at https://github.com/HUST-NingKang-Lab/Meta-Prism-2.0, and the web server can be accessed at https://hust-ningkang-lab.github.io/Meta-Prism-2.0/.
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Registered trials
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