Evidence map›Paper›PMID 35901461›Full record

ArticleArchives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists2023

Longitudinal Effects of Breast Cancer Treatment on Neural Correlates of Attention.

Robert D Melara, Tim A Ahles, Neelam Prashad, Madalyn Fernbach, Jay A Edelman, James Root

Open access · bronzeAbstract read
In one paragraph

Article in Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Article
  3. Effects of Breast Cancer Treatment on Neural Noise: a Longitudinal Design.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Robert D MelaraDepartment of Psychology, City College, City University of New York, New York, New York, USA.ORCID 0000-0002-9859-3312
Tim A AhlesDepartment of Psychiatry and Behavioral Science Services, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Neelam PrashadDepartment of Psychiatry and Behavioral Science Services, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Madalyn FernbachDepartment of Psychiatry and Behavioral Science Services, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Jay A EdelmanDepartment of Biology, City College, City University of New York, New York, New York, USA.
James RootDepartment of Psychiatry and Behavioral Science Services, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Memorial Sloan Kettering Cancer Center · USCity College of New York · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Assessment of sensory gating, attention, and executive control in breast cancerR01CA218496 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI AHLES, TIM ALAN, ROOT, JAMES C · 2018 to 2022
$3.5M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA218496NIH HHS R01 CA218496
6 · The paper itself

Abstract

objectiveCognitive dysfunction has been observed consistently in a subset of breast cancer survivors. Yet, the precise physiological and processing origins of dysfunction remain unknown. The current study examined the utility of methods and procedures based on cognitive neuroscience to study cognitive change associated with cancer and cancer treatment.

methodsWe used electroencephalogram and behavioral measures in a longitudinal design to investigate pre- versus post-treatment effects on attention performance in breast cancer patients (n = 15) compared with healthy controls (n = 24), as participants completed the revised Attention Network Test, a cognitive measure of alerting, orienting, and inhibitory control of attention.

resultsWe found no group differences in behavioral performance from pretest to posttest, but significant event-related potential effects of cancer treatment in processing cue validity: After treatment, patients revealed decreased N1 amplitude and increased P3 amplitude, suggesting a suppressed early (N1) response and an exaggerated late (P3) response to invalid cues.

conclusionsThe results suggest that treatment-related attentional disruption begins in early sensory/perceptual processing and extends to compensatory top-down executive processes.

Indexed as

Breast NeoplasmsCuesElectroencephalographyEvoked PotentialsFemaleHumansNeuropsychological TestsReaction TimeAttentionBreast cancerEEGExecutive functioningLongitudinal

Identifiers

PMID35901461
PMCPMC9868529
OpenAlexW4288384123

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.