Evidence map›Paper›PMID 35901269›Full record

ArticleBiochemistry2022

Sining Sun, Richard Wang, Maria-Eirini Pandelia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Transition metal activation reframes SAMHD1 regulation.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. The Fe and Zn cofactor dilemma.Biochimica et biophysica acta. Proteins and proteomics · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sining SunDepartment of Biochemistry, Brandeis University, Waltham, Massachusetts 02453, United States.
Richard WangDepartment of Biochemistry, Brandeis University, Waltham, Massachusetts 02453, United States.
Maria-Eirini PandeliaDepartment of Biochemistry, Brandeis University, Waltham, Massachusetts 02453, United States.ORCID 0000-0002-6750-1948
Brandeis University · US

Funding

How does a metallofactor in Hepatitis B viral protein X orchestrate pathogenesis and liver cancerR01GM126303 · NIGMS · BRANDEIS UNIVERSITY · PI PANDELIA, MARIA-EIRINI · 2019 to 2023
$1.8M
Functional diversification of the HD-superfamily; the Hydrolase/Oxygenase DilemmaR00GM111978 · NIGMS · BRANDEIS UNIVERSITY · PI PANDELIA, MARIA-EIRINI · 2016 to 2018
$740k
Functional diversification of the HD-superfamily; the Hydrolase/Oxygenase DilemmaK99GM111978 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PANDELIA, MARIA-EIRINI · 2014 to 2015
$107k
NIGMS NIH HHS K99 GM111978NIGMS NIH HHS R00 GM111978NIGMS NIH HHS R01 GM126303
6 · The paper itself

Abstract

Cyclic dinucleotides (CDNs) are signaling molecules involved in the immune response and virulence factor production. CDN cellular levels are fine-tuned by metal-dependent phosphodiesterases (PDEs), among which HD-GYPs make up a subclass of the larger HD-domain protein superfamily. The human pathogen

Indexed as

Vibrio choleraeBacterial ProteinsCatalytic DomainCyclic GMPGene Expression Regulation, BacterialHumansPhosphoric Diester HydrolasesBacterial ProteinsCyclic GMPPhosphoric Diester Hydrolases

Identifiers

PMID35901269
PMCPMC12663762
OpenAlexW4288441246

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.