ArticlePloS one2022
Coagulation abnormalities in children with uncorrected congenital heart defects seen at a teaching hospital in a developing country.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Fetal and Obstetric Complications Among Pregnant Women With Congenital Heart Disease in a Georgia Medicaid Dataset.Birth defects research · 2026Article
- Bilateral Deep Vein Thrombosis in an Adolescent with Congenital Rubella Syndrome: A Case Report.Research in heart yield and translational medicine · 2026Article
- Bleeding and Thrombotic Challenges in Children with uncorrected Cyanotic Congenital Heart Diseases (CCHD)- Experience from a tertiary care pediatric hospital.Pakistan journal of medical sciences · 2025Article
- Coagulopathy as a Complication of Cardiopulmonary Arrest Following Balloon Valvuloplasty in a Dog.Veterinary medicine and science · 2025Article
- Perioperative considerations in the paediatric patient with congenital and acquired coagulopathy.BJA open · 2024Review
- Coagulation Profile in Neonates with Congenital Heart Disease: A Pilot Study.Medicina (Kaunas, Lithuania) · 2024Article
- A Comparison of Hematological Profiles of Children With and Without Congenital Heart Defects Attending Two Selected Tertiary Hospitals.Sage open pediatricsArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoagulation abnormality is a significant complication and cause of mortality in children with uncorrected congenital heart defects (CHD). The aim of this study was to determine the prevalence of coagulation abnormalities and the associated factors in children with uncorrected CHD.
methodA cross sectional study conducted to determine the prevalence of coagulation abnormalities among 70 children with uncorrected CHD aged six months to 17 years and 70 age and sex matched apparently healthy controls. Coagulation abnormalities was determined using complete blood count, prothrombin time, activated partial thromboplastin time and D-dimer assay.
resultsThe prevalence of coagulation abnormalities among children with CHD and controls was 37.1% and 7.1% respectively. Children with Cyanotic CHD had a significantly higher prevalence of coagulation abnormalities compared to children with Acyanotic CHD (57.1% versus 17.1%). Haematocrit and oxygen saturation levels were significantly associated with coagulation abnormalities.
conclusionThis study affirms that coagulation abnormalities are frequent in children with uncorrected CHD. Oxygen saturation and haematocrit are risk factors of coagulation abnormalities. Routine coagulation screen is recommended especially in children with cyanotic congenital heart defects to improve their quality of life and reduce morbidity and mortality while awaiting definitive surgeries.
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