ArticlePloS one2022
Intraoperative hemoadsorption in high-risk patients with infective endocarditis.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- The role of hemoadsorption in cardiac surgery - a systematic review.BMC cardiovascular disorders · 2024Pooled it
- Use of intraoperative haemoadsorption in patients undergoing heart transplantation: a proof-of-concept randomized trial.ESC heart failure · 2024Trial
- The effect of hemoadsorption to patients with Stanford Type A Aortic Dissection.Journal of cardiothoracic surgery · 2026Article
- Extracorporeal Blood Purification with CytoSorb® Hemoadsorption in Valve Surgery for Infective Endocarditis: A Case Series.The American journal of case reports · 2025Article
- Efficacy of hemadsorption combining with cardiopulmonary bypass used in patients with acute type A aortic dissection.Journal of cardiothoracic surgery · 2025Article
- Decreased vasoregulatory dysfunction associated with intra-operative hemoadsorption treatment is related to mitigated post-transplant procalcitonin rather than cytokine or complement response.Frontiers in medicine · 2025Article
- The effect of HA380 blood adsorption on patients with acute infective endocarditis undergoing cardiac surgery: a retrospective study.Frontiers in cardiovascular medicine · 2025Article
- Haemoadsorption in infective endocarditis: a systematic review.Indian journal of thoracic and cardiovascular surgery · 2024Review
- Perioperative care in infective endocarditis.Indian journal of thoracic and cardiovascular surgery · 2024Review
- A Contemporary Review of the Use of Extracorporeal CytoSorbJournal of clinical medicine · 2024Review
- Adjunctive Hemoadsorption Therapy with CytoSorb in Patients with Septic/Vasoplegic Shock: A Best Practice Consensus Statement.Journal of clinical medicine · 2023Review
- Successful Extracorporeal Cytokine Hemoadsorption in a Marfan Syndrome Patient with COVID-19 Undergoing Redo Bentall Procedure.The American journal of case reports · 2023Article
- Blood purification in critically ill patients: not enough, but still helpful.Critical care (London, England) · 2023Article
- Perioperative Complications in Infective Endocarditis.Journal of clinical medicine · 2023Review
- Hemoadsorption Using CytoSorbJournal of cardiovascular development and disease · 2023Article
- Comment on 'Effect of intraoperative haemoadsorption therapy on cardiac surgery for active infective endocarditis with confirmed Staphylococcus aureus bacteraemia'.Interdisciplinary cardiovascular and thoracic surgery · 2023Article
- Reply to Amacher et al.Interdisciplinary cardiovascular and thoracic surgery · 2023Article
- Limited versus Radical Resection in Mitral Valve Infective Endocarditis Surgery.Journal of cardiovascular development and disease · 2023Article
- Intraoperative Hemoadsorption (Cytosorb™) during Open Thoracoabdominal Aortic Repair: A Pilot Randomized Controlled Trial.Journal of clinical medicine · 2023Article
- Effect of intraoperative haemoadsorption therapy on cardiac surgery for active infective endocarditis with confirmed Staphylococcus aureus bacteraemia.Interdisciplinary cardiovascular and thoracic surgery · 2023Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostoperative sepsis is an important cause of morbidity and mortality in patients with infective endocarditis undergoing surgical therapy. Blood purification using hemoadsorption therapy shows promising results in the treatment of sepsis. In this study, the clinical effects of intraoperative hemoadsorption in high-risk patients with infective endocarditis were evaluated.
methodsEligible candidates were high-risk patients with infective endocarditis undergoing cardiac surgery between January 2014 and December 2019. Patients with intraoperative hemoadsorption (hemoadsorption) were compared to patients without hemoadsorption (control). The endpoints were the incidence of postoperative sepsis, sepsis-associated death and in-hospital mortality. Additionally, postoperative vasopressor need, systemic vascular resistance indices and Sequential Organ Failure Assessment (SOFA) scores were compared.
resultsAfter propensity score matching, 70 high-risk patients were included. Postoperative sepsis occurred in 14 patients in the hemoadsorption group and in 16 patients in the control group, p = 0.629. Four patients died due to postoperative sepsis in the hemoadsorption group, while 11 postoperative septic patients died in the control group, p = 0.041. In-hospital mortality was 34% in the hemoadsorption group versus 43% in the control group, p = 0.461. On ICU-admission and the first postoperative day, the cumulative vasopressor need was 0.17 versus 0.25 μg/kgBW/min, p = 0.123 and 0.06 versus 0.11 μg/kgBW/min, p = 0.037, and the systemic vascular resistance index was 1448 versus 941 dyn·s·cm-5, p = 0.013 and 1156 versus 858 dyn·s·cm-5, p = 0.110 in the hemoadsorption versus control group, respectively. Postoperative course of SOFA score normalized significantly (p = 0.01) faster in the hemoadsorption group.
conclusionsIn high-risk cardiac surgical patients with infective endocarditis, intraoperative hemoadsorption significantly reduced sepsis-associated mortality. Furthermore, intraoperative hemoadsorption resulted in significant faster recovery of hemodynamics and organ function. Intraoperative hemoadsorption seems to attenuate the severity of postoperative sepsis.
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