Evidence map›Paper›PMID 35900719›Full record

ArticleTranslational stroke research2023

Multinuclear MRI Reveals Early Efficacy of Stem Cell Therapy in Stroke.

Shannon Helsper, Xuegang Yuan, F Andrew Bagdasarian, Jacob Athey, Yan Li, Cesario V Borlongan, Samuel C Grant

Open access · greenAbstract read
In one paragraph

Article in Translational stroke research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Shannon HelsperThe National High Magnetic Field Laboratory, Florida State University, 1800 E. Paul Dirac Dr, Tallahassee, FL, 32310, USA.
Xuegang YuanThe National High Magnetic Field Laboratory, Florida State University, 1800 E. Paul Dirac Dr, Tallahassee, FL, 32310, USA.
F Andrew BagdasarianThe National High Magnetic Field Laboratory, Florida State University, 1800 E. Paul Dirac Dr, Tallahassee, FL, 32310, USA.
Jacob AtheyDepartment of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Florida State University, Tallahassee, FL, 32310, USA.
Yan LiDepartment of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Florida State University, Tallahassee, FL, 32310, USA.
Cesario V BorlonganCenter of Excellence for Aging & Brain Repair, University of South Florida, Tampa, FL, 33612, USA.
Samuel C GrantThe National High Magnetic Field Laboratory, Florida State University, 1800 E. Paul Dirac Dr, Tallahassee, FL, 32310, USA. grant@magnet.fsu.edu.
Florida A&M University - Florida State University College of Engineering · USFlorida State University · USNational High Magnetic Field Laboratory · USUniversity of South Florida · US

Funding

MR Analysis of Pre-Conditioned Human Mesenchymal Stem Cells for Stroke TherapyR01NS102395 · NINDS · FLORIDA STATE UNIVERSITY · PI GRANT, SAMUEL COLLES · 2017 to 2021
$1.7M
Investigation into hMSC-derived therapy in ischemic stroke at high field MRimaging and spectroscopyF31NS115409 · NINDS · FLORIDA STATE UNIVERSITY · PI HELSPER, SHANNON · 2020 to 2022
$116k
NINDS NIH HHS F31 NS115409NINDS NIH HHS F31-NS115409NINDS NIH HHS R01 NS102395NINDS NIH HHS RO1-NS102395
6 · The paper itself

Abstract

Compromised adult human mesenchymal stem cells (hMSC) can impair cell therapy efficacy and further reverse ischemic recovery. However, in vitro assays require extended passage to characterize cells, limiting rapid assessment for therapeutic potency. Multinuclear magnetic resonance imaging and spectroscopy (MRI/S) provides near real-time feedback on disease progression and tissue recovery. Applied to ischemic stroke,

Indexed as

Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationStrokeAdultHumansInfarction, Middle Cerebral ArteryMagnetic Resonance ImagingHuman mesenchymal stem cellsIschemic strokeMagnetic resonance imagingNMR spectroscopyRatSodium

Identifiers

PMID35900719
PMCPMC10733402
OpenAlexW4288074554

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.