Evidence map›Paper›PMID 35900669›Full record

ArticleCEN case reports2023

Severe leukocytopenia due to copper deficiency induced by zinc supplementation in a patient on peritoneal dialysis: a case report.

Yoshiki Kimura, Yuki Mori, Shoki Notsu, Saki Bessho, Aimi Kobori, Takuya Kubota, Akihiro Shimomura, Hirotsugu Iwatani

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in CEN case reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yoshiki KimuraDepartment of Nephrology, National Hospital Organization Osaka National Hospital, 2-1-14, Hoenzaka Chuo-ku, Osaka, 540-0006, Japan.
Yuki MoriDepartment of Nephrology, National Hospital Organization Osaka National Hospital, 2-1-14, Hoenzaka Chuo-ku, Osaka, 540-0006, Japan.
Shoki NotsuDepartment of Nephrology, National Hospital Organization Osaka National Hospital, 2-1-14, Hoenzaka Chuo-ku, Osaka, 540-0006, Japan.
Saki BesshoDepartment of Nephrology, National Hospital Organization Osaka National Hospital, 2-1-14, Hoenzaka Chuo-ku, Osaka, 540-0006, Japan.
Aimi KoboriDepartment of Nephrology, National Hospital Organization Osaka National Hospital, 2-1-14, Hoenzaka Chuo-ku, Osaka, 540-0006, Japan.
Takuya KubotaDepartment of Nephrology, National Hospital Organization Osaka National Hospital, 2-1-14, Hoenzaka Chuo-ku, Osaka, 540-0006, Japan.
Akihiro ShimomuraDepartment of Nephrology, National Hospital Organization Osaka National Hospital, 2-1-14, Hoenzaka Chuo-ku, Osaka, 540-0006, Japan.
Hirotsugu IwataniDepartment of Nephrology, National Hospital Organization Osaka National Hospital, 2-1-14, Hoenzaka Chuo-ku, Osaka, 540-0006, Japan. hiwatani-npr@umin.ac.jp.
Osaka National Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zinc deficiency is one cause of anemia. However, it has been reported that some patients who were treated with zinc supplementation to resolve this anemia subsequently experienced copper deficiency, which lead to continued anemia, as well as leukocytopenia and other symptoms. However, only two patients with copper deficiency induced by zinc supplementation undergoing peritoneal dialysis have been reported. Here, we report the case of a 59 year-old man with copper deficiency after zinc supplementation undergoing peritoneal dialysis (PD). He took meals only once a day and drank about 750 mL/day of wine every day. He had been receiving zinc supplementation for 4 months. He was diagnosed with severe leukocytopenia and worsening anemia at a planned outpatient visit; in addition, his copper levels had markedly decreased. Thus, zinc supplementation was discontinued, and the patient was instructed to take cocoa for copper supplementation. Because of severe leukocytopenia, he was admitted to our hospital, and granulocyte colony-stimulating factor was administered. Red blood cell transfusions were performed for anemia. After discontinuing zinc supplementation, his white blood cell count and hemoglobin levels improved.To avoid Cu deficiency, patients' dietary history should be checked in detail and Cu should be monitored carefully when Zn is supplemented in patients undergoing PD.

Indexed as

AnemiaLeukopeniaPeritoneal DialysisCopperDietary SupplementsHumansMaleMiddle AgedZincCopperZincCopper deficiencyLeukocytopeniaPeritoneal dialysisZinc supplementation

Identifiers

PMID35900669
PMCPMC9892407
OpenAlexW4288435675

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.