ArticleMolecular diversity2024
New oxacycles on the block: benzodioxepinones via a Passerini reaction.
Article in Molecular diversity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- A Three-Layer Transformation Strategy toward Functionalized Fused Hydantoins and Diketopiperazines.Organic letters · 2026Article
- Multicomponent reactions driving the discovery and optimization of agents targeting central nervous system pathologies.Beilstein journal of organic chemistry · 2024Review
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Authors and funding
4 authors.
Funding
Abstract
Oxacycles and benzoxepanes are privileged motifs present in a variety of natural products and functional molecules. However, their synthetic access is limited. Here, we demonstrate a rapid synthesis of unprecedented benzoxepanes from readily available starting materials in one step via a Passerini multicomponent reaction. The reaction proceeds smoothly under mild reaction conditions. We have obtained a single-crystal X-ray structure, revealing a butterfly conformation, combined with useful structural features. In addition, we have performed both a full interaction map on the X-ray structure and a profile analysis of a virtual library based on the proposed scaffold with a special focus on certain physicochemical parameters to demonstrate their potential usage in drug discovery.
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Registered trials
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