Evidence map›Paper›PMID 35900620›Full record

ArticleInsights into imaging2022

Detection of distant metastases and distant second primary cancers in head and neck squamous cell carcinoma: comparison of [

Eirini Katirtzidou, Olivier Rager, Arthur Damien Varoquaux, Antoine Poncet, Vincent Lenoir, Nicolas Dulguerov, Alexandra Platon, Valentina Garibotto, Habib Zaidi, Minerva Becker

Open access · goldAbstract read
In one paragraph

Article in Insights into imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. The Diagnostic and Prognostic Value ofDiagnostics (Basel, Switzerland) · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 3 countries.

Eirini KatirtzidouDivision of Radiology, Diagnostic Department, Geneva University Hospitals, University of Geneva, Rue Gabrielle Perret Gentil 4, CH-1205, Geneva, Switzerland.
Olivier RagerDivision of Nuclear Medicine, Diagnostic Department, Geneva University Hospitals, University of Geneva, Geneva, Switzerland.
Arthur Damien VaroquauxDivision of Radiology, Diagnostic Department, Geneva University Hospitals, University of Geneva, Rue Gabrielle Perret Gentil 4, CH-1205, Geneva, Switzerland.
Antoine PoncetCenter for Clinical Research, Geneva University Hospitals, University of Geneva, Geneva, Switzerland.
Vincent LenoirDivision of Radiology, Diagnostic Department, Geneva University Hospitals, University of Geneva, Rue Gabrielle Perret Gentil 4, CH-1205, Geneva, Switzerland.
Nicolas DulguerovClinic for Otorhinolaryngology, Department of Clinical Neurosciences, Geneva University Hospitals, University of Geneva, Geneva, Switzerland.
Alexandra PlatonDivision of Radiology, Diagnostic Department, Geneva University Hospitals, University of Geneva, Rue Gabrielle Perret Gentil 4, CH-1205, Geneva, Switzerland.
Valentina GaribottoDivision of Nuclear Medicine, Diagnostic Department, Geneva University Hospitals, University of Geneva, Geneva, Switzerland.
Habib ZaidiDivision of Nuclear Medicine, Diagnostic Department, Geneva University Hospitals, University of Geneva, Geneva, Switzerland.
Minerva BeckerDivision of Radiology, Diagnostic Department, Geneva University Hospitals, University of Geneva, Rue Gabrielle Perret Gentil 4, CH-1205, Geneva, Switzerland. Minerva.Becker@hcuge.ch.ORCID http://orcid.org/0000-0001-9644-9053
University of Geneva · CH

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung grant SNSF No 320030_173091/1.
6 · The paper itself

Abstract

purposeThis prospective study aimed to compare the diagnostic performance of [

methodsA total of 103 [

resultsDistant metastases and distant second primary cancers were present in 23/103 (22%) examinations in 16/82 (19.5%) patients, and they were more common in the post-treatment group (11/41, 27%) than in the primary HNSCC group (3/38, 8%), p = 0.039. The area under the curve (AUC) per patient/examination/lesion was 0.947 [0.927-1]/0.965 [0.917-1]/0.957 [0.928-0.987] for PET/MRI and 0.975 [0.950-1]/0.968 [0.920-1]/0.944 [0.910-0.979] for PET/CT, respectively (p > 0.05). The diagnostic performance of PET/MRI and PET/CT was similar according to JAFROC (p = 0.919) and ROI-based ROC analysis (p = 0.574). Sensitivity/specificity/accuracy for PET/MRI and PET/CT for a score ≥ 3 was 94%/88%/89% and 94%/91%/91% per patient, 96%/90%/91% and 96%/93%/93% per examination and 95%/85%/90% and 90%/86%/88% per lesion, respectively, p > 0.05.

conclusionsIn HNSCC patients, PET/MRI and PET/CT had a high and similar diagnostic performance for detecting distant metastases and distant second primary cancers.

Indexed as

Head and neck tumorsMetastasesPET/CTPET/MRISecond primary cancer

Identifiers

PMID35900620
PMCPMC9334511
OpenAlexW4288084936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.