Evidence map›Paper›PMID 35900439›Full record

ArticleNeural regeneration research2023

Treatment of radiation-induced brain injury with bisdemethoxycurcumin.

Yun-Qian Chang, Gui-Juan Zhou, Hong-Mei Wen, Duan-Qun He, Chen-Lin Xu, Ya-Rui Chen, Yi-Hui Li, Shuang-Xi Chen, Zi-Jian Xiao, Ming Xie

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yun-Qian ChangDepartment of Neurology, The First Affiliated Hospital; Department of Neurology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan Province, China.
Gui-Juan ZhouDepartment of Neurology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan Province, China.
Hong-Mei WenDepartment of Nursing, Youxian People's Hospital, Zhuzhou, Hunan Province, China.
Duan-Qun HeDepartment of Neurology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan Province; Department of Neurology, Shenzhen Baoan People's Hospital (Group), The Second People's Hospital, Shenzhen, Guangdong Province, China.
Chen-Lin XuDepartment of Neurology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan Province; Department of Neurology, Xiangxi Autonomous Prefecture People's Hospital, Jishou, Hunan Province, China.
Ya-Rui ChenDepartment of Neurology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan Province, China.
Yi-Hui LiDepartment of Neurology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan Province, China.
Shuang-Xi ChenDepartment of Neurology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan Province, China.
Zi-Jian XiaoDepartment of Neurology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan Province, China.
Ming XieDepartment of Neurology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan Province, China.
University of South China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiation therapy is considered the most effective non-surgical treatment for brain tumors. However, there are no available treatments for radiation-induced brain injury. Bisdemethoxycurcumin (BDMC) is a demethoxy derivative of curcumin that has anti-proliferative, anti-inflammatory, and anti-oxidant properties. To determine whether BDMC has the potential to treat radiation-induced brain injury, in this study, we established a rat model of radiation-induced brain injury by administering a single 30-Gy vertical dose of irradiation to the whole brain, followed by intraperitoneal injection of 500 μL of a 100 mg/kg BDMC solution every day for 5 successive weeks. Our results showed that BDMC increased the body weight of rats with radiation-induced brain injury, improved learning and memory, attenuated brain edema, inhibited astrocyte activation, and reduced oxidative stress. These findings suggest that BDMC protects against radiation-induced brain injury.

Indexed as

astrocytesbisdemethoxycurcuminbrain edemabrain tumorcurcuminlearning and memoryneuronal injuryoxidative stressradiation-induced brain injuryradiation therapy

Identifiers

PMID35900439
PMCPMC9396486
OpenAlexW4285724953

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.