Evidence map›Paper›PMID 35900437›Full record

ArticleNeural regeneration research2023

Neural stem cell-derived exosome as a nano-sized carrier for BDNF delivery to a rat model of ischemic stroke.

Zhi-Han Zhu, Feng Jia, Waqas Ahmed, Gui-Long Zhang, Hong Wang, Chao-Qun Lin, Wang-Hao Chen, Lu-Kui Chen

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06612710 (An Open-label Exploratory Clinical Trial to Assess the Safety and Efficacy of NouvSoma001 in the Treatment of Ischemic Stroke), which is not on this map. Cited by 69 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 2 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06612710 phase1recruitingnot on this mapstarted 2025, after this paper: background citation

An Open-label Exploratory Clinical Trial to Assess the Safety and Efficacy of NouvSoma001 in the Treatment of Ischemic Stroke

TypeinterventionalSponsorWei WangRan2025 to 2027Enrolled69ConditionsIschemic StrokeArmsextracellular vesicles derived from human induced neural stem cell for intravenous injection, a placebo of extracellular vesicles derived from human induced neural stem cell for intravenous injection
3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 122 citations in OpenAlex.

  1. Pooled it
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  4. The Role and Diagnostic Efficacy of the METTL14/GADD45B mCellular and molecular neurobiology · 2026
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Zhi-Han ZhuDepartment of Neurosurgery, School of Medicine, Southeast University, Nanjing, Jiangsu Province, China.
Feng JiaDepartment of Neurosurgery, Neuroscience Center, Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong Province, China.
Waqas AhmedDepartment of Neurosurgery, School of Medicine, Southeast University, Nanjing, Jiangsu Province, China.
Gui-Long ZhangDepartment of Neurosurgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China.
Hong WangDepartment of Neurosurgery, School of Medicine, Southeast University, Nanjing, Jiangsu Province, China.
Chao-Qun LinDepartment of Neurosurgery, School of Medicine, Southeast University, Nanjing, Jiangsu Province, China.
Wang-Hao ChenDepartment of Neurosurgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lu-Kui ChenDepartment of Neurosurgery, School of Medicine, Southeast University, Nanjing, Jiangsu Province; Department of Neurosurgery, Neuroscience Center, Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong Province, China.
Southeast University · CNSecond Affiliated Hospital of Guangzhou Medical University · CNShanghai Ninth People's Hospital · CNTCM-Intigrated Cancer Center of Southern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our previous study demonstrated the potential therapeutic role of human neural stem cell-derived exosomes (hNSC-Exo) in ischemic stroke. Here, we loaded brain-derived neurotrophic factor (BDNF) into exosomes derived from NSCs to construct engineered exosomes (BDNF-hNSC-Exo) and compared their effects with those of hNSC-Exo on ischemic stroke both in vitro and in vivo. In a model of H

Indexed as

brain-derived neurotrophic factorexosomeinflammationischemic strokeneural stem cellneurogenesisneurological recoverytransplantation

Identifiers

PMID35900437
PMCPMC9396474
OpenAlexW4285724878

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.