Evidence map›Paper›PMID 35900434›Full record

ArticleNeural regeneration research2023

Neuroprotective effects of exogenous brain-derived neurotrophic factor on amyloid-beta 1-40-induced retinal degeneration.

Mohd Aizuddin Mohd Lazaldin, Igor Iezhitsa, Renu Agarwal, Puneet Agarwal, Nafeeza Mohd Ismail

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Mohd Aizuddin Mohd LazaldinDepartment of Biosciences, Faculty of Science, Universiti Teknologi Malaysia, Johor Bahru, Malaysia.
Igor IezhitsaSchool of Medicine, International Medical University, Kuala Lumpur, Malaysia; Department of Pharmacology and Bioinformatics, Volgograd State Medical University, Volgograd, Russia.
Renu AgarwalSchool of Medicine, International Medical University, Kuala Lumpur, Malaysia.
Puneet AgarwalSchool of Medicine, International Medical University, Kuala Lumpur, Malaysia.
Nafeeza Mohd IsmailFaculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Selangor, Malaysia.
International Medical University · MYUniversiti Teknologi MARA · MYUniversity of Technology Malaysia · MYVolgograd State Medical University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyloid-beta (Aβ)-related alterations, similar to those found in the brains of patients with Alzheimer's disease, have been observed in the retina of patients with glaucoma. Decreased levels of brain-derived neurotrophic factor (BDNF) are believed to be associated with the neurotoxic effects of Aβ peptide. To investigate the mechanism underlying the neuroprotective effects of BDNF on Aβ

Indexed as

amyloid-beta 1–40brain-derived neurotrophic factorFluoro-Goldneuroprotectionretinal ganglion cells (RGC)retinal toxicitytropomyosin receptor kinase B (TrkB)

Identifiers

PMID35900434
PMCPMC9396500
OpenAlexW4285724930

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.