ArticleJournal of mass spectrometry : JMS2022
Novel matrix strategies for improved ionization and spatial resolution using IR-MALDESI mass spectrometry imaging.
Article in Journal of mass spectrometry : JMS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Spatially resolved lipids in a mouse brain model of globoid cell leukodystrophy via IR-MALDESI MSI and parallel reaction monitoring MSI.Analytical and bioanalytical chemistry · 2026Article
- Effects of Inlet Capillary Temperature in Atmospheric-Pressure Infrared Laser-Ablation Plasma Postionization Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2025Article
- Three-dimensional mass spectrometry imaging (3D MSI): incorporating top-hat IR-MALDESI and automatic z-axis correction.Analytical and bioanalytical chemistry · 2025Article
- Optimizing neurotransmitter pathway detection by IR-MALDESI-MSI in mouse brain.Analytical and bioanalytical chemistry · 2024Article
- SMART: A data reporting standard for mass spectrometry imaging.Journal of mass spectrometry : JMS · 2023Article
- Developing transmission mode for infrared matrix-assisted laser desorption electrospray ionization mass spectrometry imaging.Rapid communications in mass spectrometry : RCM · 2022Article
- Article
- Novel matrix strategies for improved ionization and spatial resolution using IR-MALDESI mass spectrometry imaging.Journal of mass spectrometry : JMS · 2022Article
- Integrating Remote Sensing and Metabolomics to Assess Synergistic Effects of Phosphate Deficiency, Drought, and AMF Symbiosis in Soybean.Physiologia plantarumArticle
- Mass spectrometry imaging of N-linked glycans: Fundamentals and recent advances.Mass spectrometry reviewsReview
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In mass spectrometry imaging (MSI) applications of infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI), an exogenous ice layer is the gold standard for an energy-absorbing matrix. However, the formation of the ice matrix requires additional time and instrument hardware, so glycerol was investigated herein as an alternative to the ice matrix to potentially improve spatial resolution and ionization, while decreasing experiment time. Glycerol solutions of varying concentrations were sprayed over top of rat liver tissue sections for analysis by IR-MALDESI and compared to the typical ice matrix condition. Additionally, we tested if combining the ice matrix and glycerol matrix would further improve analyses. Matrix conditions were evaluated by comparing ion abundance of six lipid species, the laser ablation spot diameter, and number of METASPACE annotations. The ion abundances were also normalized to the volume of tissue ablated to correct for lower abundance values due to less ablated tissue. It was observed that utilizing a 50% glycerol matrix without ice provides improved spatial resolution with lipid abundances and annotations comparable to the ice matrix standard, while decreasing the time required to complete an IR-MALDESI tissue imaging experiment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.