Evidence map›Paper›PMID 35900342›Full record

ArticleAmerican journal of physiology. Renal physiology2022

Chronic activation of vasopressin-2 receptors induces hypertension in Liddle mice by promoting Na

James D Stockand, Elena V Mironova, Hong Xiang, Antonio G Soares, Jorge Contreras, James A McCormick, Susan B Gurley, Alan C Pao

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. ENaC processing in rat kidney: effects of salt loading and ADH.American journal of physiology. Renal physiology · 2026
    Article
  3. Ovarian hormones moderate systolic hypertension in femaleAmerican journal of physiology. Renal physiology · 2026
    Article
  4. Article
  5. Ovarian Hormones Moderate Systolic Hypertension in FemalebioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

James D StockandDepartment of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas.ORCID 0000-0002-3817-4319
Elena V MironovaDepartment of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Hong XiangDivision of Nephrology, Department of Medicine, Stanford University School of Medicine, Palo Alto, California.
Antonio G SoaresDepartment of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Jorge ContrerasDepartment of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas.ORCID 0000-0001-7890-7145
James A McCormickDivision of Nephrology and Hypertension, Oregon Health and Science University, Portland, Oregon.ORCID 0000-0003-4000-6653
Susan B GurleyDivision of Nephrology and Hypertension, Oregon Health and Science University, Portland, Oregon.
Alan C PaoDivision of Nephrology, Department of Medicine, Stanford University School of Medicine, Palo Alto, California.ORCID 0000-0001-8589-9083
The University of Texas Health Science Center at San Antonio · USOregon Health & Science University · USStanford University · USVA Palo Alto Health Care System · US

Funding

Renal Genomics CoreP30DK096493 · NIDDK · DUKE UNIVERSITY · PI COFFMAN, THOMAS M · 2012 to 2016
$5.9M
Regulation of sodium transport and blood pressure by SPAK/OSR1 kinasesR01DK098141 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI JAMES A MCCORMICK, Ujwal Shinde · 2014 to 2026
$4.2M
Defining the Contribution of ENaC to ADH-mediated Water and Sodium ExcretionR01DK103758 · NIDDK · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI PAO, ALAN C, STOCKAND, JAMES D · 2016 to 2019
$1.3M
NIDDK NIH HHS P30 DK096493NIDDK NIH HHS R01 DK098141NIDDK NIH HHS R01 DK103758
6 · The paper itself

Abstract

The renin-angiotensin-aldosterone and arginine vasopressin-V2 receptor-aquaporin-2 (AQP2) systems converge on the epithelial Na

Indexed as

HypertensionWater-Electrolyte ImbalanceAnimalsAquaporin 2Deamino Arginine VasopressinEpithelial Sodium ChannelsMiceReceptors, VasopressinSodiumWaterAquaporin 2Deamino Arginine VasopressinEpithelial Sodium ChannelsReceptors, VasopressinSodiumWatercollecting ductepithelial Na+ channelLiddle syndromevasopressinvasopressin-2 receptor

Identifiers

PMID35900342
PMCPMC9485005
OpenAlexW4288441845

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.