The fetal lineage is susceptible to Zika virus infection within days of fertilization.

Open access · hybridAbstract read

In one paragraph

Article in Development (Cambridge, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.6field-weighted citation impact, top 31% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

The Antiviral Potential of AdipoRon, an Adiponectin Receptor Agonist, Reveals the Ability of Zika Virus to Deregulate Adiponectin Receptor Expression.Viruses · 2023
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jennifer L WattsMolecular, Cellular and Integrative Physiology Graduate Program, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0001-8932-325X

Amy RalstonReproductive and Developmental Biology Training Program, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0003-3755-8262

Michigan State University · US

Funding

Molecular mechanisms regulating formation of diverse stem cell progenitorsR35GM131759 · NIGMS · MICHIGAN STATE UNIVERSITY · PI Amy Ralston · 2019 to 2026

$3.0M

Reproductive and Developmental Sciences Training Program - T32T32HD087166 · NICHD · MICHIGAN STATE UNIVERSITY · PI Ronald L Chandler, Keith E Latham · 2016 to 2026

$2.5M

NICHD NIH HHS T32 HD087166NIGMS NIH HHS R35 GM131759

6 · The paper itself

Abstract

Adults contracting Zika virus (ZIKV) typically exhibit mild symptoms, yet ZIKV infection of pregnant individuals can cause miscarriage or birth defects in their offspring. Many studies have focused on maternal-to-fetal ZIKV transmission via blood and placenta. Notably, however, ZIKV is also transmitted sexually, raising the possibility that ZIKV could infect the embryo shortly after fertilization, long before the placenta is established. Here, we evaluate the consequences of ZIKV infection in mouse embryos during the first few days of embryogenesis. We show that divergent strains of ZIKV can infect the fetal lineage and can cause developmental arrest, raising concern for the developmental consequences of sexual ZIKV transmission. This article has an associated 'The people behind the papers' interview.

Indexed as

Zika VirusZika Virus InfectionAnimalsDisease SusceptibilityFemaleFertilizationFetusHumansInfectious Disease Transmission, VerticalMicePregnancyBirth defectsCell fateDevelopmental biologyEpidemicMiscarriageZika virus (ZIKV)

Identifiers

PMID35900100

DOI10.1242/dev.200501

PMCPMC9382896

OpenAlexW4288096950

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.