Evidence map›Paper›PMID 35899367›Full record

ReviewJournal of cellular and molecular medicine2022

Molecular feature of neutrophils in immune microenvironment of muscle atrophy.

Zongqi You, Xinying Huang, Yaoxian Xiang, Junxi Dai, Junjian Jiang, Jianguang Xu

Open access · goldAbstract readReview
In one paragraph

Review in Journal of cellular and molecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Zongqi YouDepartment of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Xinying HuangDepartment of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Yaoxian XiangDepartment of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Junxi DaiDepartment of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Junjian JiangDepartment of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0001-6087-1308
Jianguang XuDepartment of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Fudan University · CN

Funding

Shanghai Municipal Key Clinical Specialty shslczdzk05601
6 · The paper itself

Abstract

Homeostasis in skeletal muscle is sustained by the balance of functional and physical interactions between muscle and myofibre microenvironment. Various factors, such as ageing, disuse and denervation, tip the balance and induce skeletal muscle atrophy. Skeletal muscle atrophy, which involves complex physiological and biochemical changes, is accompanied by adverse outcomes and even increased mortality. Multiple studies have investigated the role of neutrophils in atrophied skeletal muscles; however, neutrophil intrusion in muscle is still a polemical knot. As technical obstacles have been overcome, people have gradually discovered new functions of neutrophils. The classical view of neutrophils is no longer applicable to their biological characteristics. To date, no clear association between the hidden injurious effect of neutrophil intrusion and muscle atrophy has been convincingly proven. Throughout this review, we have discussed the neutrophil activities that mediate muscle atrophy for distinct disease occurrences. Hopefully, this review will help both clinicians and researchers of skeletal muscle atrophy with relevant targets to further explore efficient medical interventions and treatments.

Indexed as

Muscular AtrophyNeutrophilsAgingHumansMuscle, Skeletalatrophyimmune microenvironmentNeutrophilsskeletal muscle

Identifiers

PMID35899367
PMCPMC9443939
OpenAlexW4288448940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.