Evidence map›Paper›PMID 35899286›Full record

ArticleOpen forum infectious diseases2022

Management of Histoplasmosis by Infectious Disease Physicians.

Patrick B Mazi, Sandra R Arnold, John W Baddley, Nathan C Bahr, Susan E Beekmann, Todd P McCarty, Philip M Polgreen, Adriana M Rauseo, Andrej Spec

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
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  4. Neoaortoiliac reconstruction for aJournal of vascular surgery cases and innovative techniques · 2026
    Article
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  7. Article
  8. Review
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  11. Article
  12. Article
  13. Article
  14. Article
  15. Genotypic diversity, virulence, and molecular genetic tools inMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  16. Article
  17. Article
  18. Review
  19. The Geographic Distribution of Dimorphic Mycoses in the United States for the Modern Era.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Patrick B MaziDivision of Infectious Diseases, Washington University in St Louis, St Louis, Missouri, USA.ORCID https://orcid.org/0000-0003-4123-0518
Sandra R ArnoldDivision of Pediatric Infectious Diseases, Le Bonheur Children's Hospital, Memphis, Tennessee, USA.
John W BaddleyDivision of Infectious Diseases, University of Maryland, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0001-9111-625X
Nathan C BahrDivision of Infectious Diseases, University of Kansas, Kansas City, Kansas, USA.
Susan E BeekmannDivision of Infectious Diseases, University of Iowa, Iowa City, Iowa, USA.
Todd P McCartyDivision of Infectious Diseases, University of Alabama, Birmingham, Alabama, USA.
Philip M PolgreenDivision of Infectious Diseases, University of Iowa, Iowa City, Iowa, USA.
Adriana M RauseoDivision of Infectious Diseases, Washington University in St Louis, St Louis, Missouri, USA.ORCID https://orcid.org/0000-0001-9555-2550
Andrej SpecDivision of Infectious Diseases, Washington University in St Louis, St Louis, Missouri, USA.ORCID https://orcid.org/0000-0001-7612-4710

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
Novel Diagnostic Development for TB Meningitis and HistoplasmosisK23NS110470 · NINDS · UNIVERSITY OF MINNESOTA · PI BAHR, NATHAN · 2019 to 2023
$1.0M
NCATS NIH HHS UL1 TR002345NIDDK NIH HHS P30 DK054759NINDS NIH HHS K23 NS110470
6 · The paper itself

Abstract

Background: The Infectious Diseases Society of America (IDSA) guidelines for the management of histoplasmosis were last revised 15 years ago. Since those guidelines were compiled, new antifungal treatment options have been developed. Furthermore, the ongoing development of immunomodulatory therapies has increased the population at increased risk to develop histoplasmosis. Methods: An electronic survey about the management practices of histoplasmosis was distributed to the adult infectious disease (ID) physician members of the IDSA's Emerging Infections Network. Results: The survey response rate was 37% (551/1477). Only 46% (253/551) of respondents reported seeing patients with histoplasmosis. Regions considered endemic had 82% (158/193) of physicians report seeing patients with histoplasmosis compared to 27% (95/358) of physicians in regions not classically considered endemic ( Conclusions: Though there are increased reports of histoplasmosis diagnoses outside regions classically considered endemic, a majority of ID physicians reported not seeing patients with histoplasmosis. Most respondents reported adherence to IDSA guidelines recommending itraconazole in each clinical situation. New histoplasmosis guidelines need to reflect the growing need for updated general guidance, particularly for immunocompromised populations.

Indexed as

amphotericinclinical practiceHistoplasma capsulatumhistoplasmosisitraconazole

Identifiers

PMID35899286
PMCPMC9310261

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.