Evidence map›Paper›PMID 35899276›Full record

ArticleOpen forum infectious diseases2022

Comparison of Sequential Dalbavancin With Standard-of-Care Treatment for

Kyle C Molina, Cali Lunowa, Madelyn Lebin, Andrea Segerstrom Nunez, Sara F Azimi, Martin Krsak, Scott W Mueller, Matthew A Miller

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06266494 (Prevention and Treatment of Frostbite Infection With Antimicrobial Pharmacokinetic Analysis), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06266494 phase4recruitingnot on this mapstarted 2024, after this paper: background citation

Prevention and Treatment of Frostbite Infection With Antimicrobial Pharmacokinetic Analysis

TypeinterventionalSponsorUniversity of Colorado, DenverRan2024 to 2026Enrolled100ConditionsFrostbiteArmsLong-Acting silver dressings, Aloe Vera, Dalbavancin
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Contemporary Management of Staphylococcus aureus Bacteremia-Controversies in Clinical Practice.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Review
  7. Review
  8. New Approaches to Manage Infections in Transplant Recipients: Report From the 2023 GTI (Infection and Transplantation Group) Annual Meeting.Transplant international : official journal of the European Society for Organ Transplantation · 2023
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Kyle C MolinaDepartment of Pharmacy, University of Colorado Hospital, Aurora, Colorado, USA.ORCID https://orcid.org/0000-0002-6764-5984
Cali LunowaDepartment of Pharmacy, University of Colorado Hospital, Aurora, Colorado, USA.
Madelyn LebinDepartment of Pharmacy, University of Colorado Hospital, Aurora, Colorado, USA.
Andrea Segerstrom NunezDepartment of Pharmacy, University of Colorado Hospital, Aurora, Colorado, USA.
Sara F AzimiDepartment of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado, USA.
Martin KrsakDivision of Infectious Diseases, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.
Scott W MuellerDepartment of Pharmacy, University of Colorado Hospital, Aurora, Colorado, USA.
Matthew A MillerDepartment of Pharmacy, University of Colorado Hospital, Aurora, Colorado, USA.
University of Colorado Hospital · USUniversity of Colorado Denver · USUniversity of Montana · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Dalbavancin (DAL) is a long-acting lipoglycopeptide with activity against Methods: We conducted a retrospective cohort study from 2014 to 2021 comparing sequential DAL with standard-of-care therapy (SoC) for Results: Overall, 225 patients (45 DAL, 180 SoC) were included. DAL patients had a higher incidence of community-acquired infection and persons who use drugs; SoC patients had more comorbidities and a longer duration of bacteremia. MRSA incidence was similar between the DAL and SoC groups. The median length of stay was 16 days among DAL recipients compared with 24 days among SoC recipients. Central catheter placement was 17.8% compared with 57.2% in the SoC group. Ninety-day clinical failure occurred in 13.3% and 18.3% of participants in the DAL and SOC groups, respectively. In IPTW-adjusted analysis, sequential DAL was not associated with 90-day clinical failure (adjusted odds ratio, 0.94; 95% CI, 0.333-2.32). Conclusions: This study provides preliminary evidence that select patients with

Indexed as

BSIlong-acting lipoglycopeptidesMRSASAB

Identifiers

PMID35899276
PMCPMC9314917
OpenAlexW4285389084

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.