Evidence map›Paper›PMID 35899244›Full record

ArticleAcute medicine & surgery

Insulin overdose complicated by treatment-induced acute hepatic steatosis in a nondiabetic patient.

Noriyuki Okamoto, Shinsuke Onishi, Toshiyuki Onodera, Toshihiro Tawara, Hiroyuki Okamoto, Takafumi Shimizu, Akiko Oshiro, Yuka Morishita, Satoshi Nara

Open access · goldAbstract readCase Reports
In one paragraph

Article in Acute medicine & surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Noriyuki OkamotoEmergency and Critical Care Medical Center Teine Keijinkai Hospital Sapporo Hokkaido Japan.ORCID https://orcid.org/0000-0002-9510-1765
Shinsuke OnishiEmergency and Critical Care Medical Center Teine Keijinkai Hospital Sapporo Hokkaido Japan.
Toshiyuki OnoderaEmergency and Critical Care Medical Center Teine Keijinkai Hospital Sapporo Hokkaido Japan.
Toshihiro TawaraEmergency and Critical Care Medical Center Teine Keijinkai Hospital Sapporo Hokkaido Japan.
Hiroyuki OkamotoEmergency and Critical Care Medical Center Teine Keijinkai Hospital Sapporo Hokkaido Japan.
Takafumi ShimizuEmergency and Critical Care Medical Center Teine Keijinkai Hospital Sapporo Hokkaido Japan.
Akiko OshiroEmergency and Critical Care Medical Center Teine Keijinkai Hospital Sapporo Hokkaido Japan.
Yuka MorishitaEmergency and Critical Care Medical Center Teine Keijinkai Hospital Sapporo Hokkaido Japan.
Satoshi NaraEmergency and Critical Care Medical Center Teine Keijinkai Hospital Sapporo Hokkaido Japan.
Teine Keijinkai Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: There are few reports of dextrose-associated hepatic steatosis during insulin overdose treatment. Reports in nondiabetic patients are extremely rare. There is inadequate knowledge about the clinical course and treatment. Case Presentation: A 37-year-old previously healthy, nondiabetic man self-administered 5,925 IU of insulin. On admission, his liver function tests were normal. However, following continued dextrose treatment, they increased, and he was diagnosed with hepatic steatosis. The liver function tests improved with decreasing dextrose dosage, and he was asymptomatic on discharge. Conclusion: Acute hepatic steatosis may occur in nondiabetic and diabetic patients during treatment requiring large doses of dextrose infusion, such as for an insulin overdose. In addition, the degree of liver damage might also be related to the dextrose dose. Therefore, careful glycemic control and minimization of the dextrose dosage are recommended for diabetic and nondiabetic patients.

Indexed as

Dextrosedrug overdosehepatic steatosisinsulinliver injury

Identifiers

PMID35899244
PMCPMC9307883
OpenAlexW4286693013

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.