Evidence map›Paper›PMID 35898812›Full record

ArticleInternational journal of pharmaceutics: X2022

Identification of novel cyanoacrylate monomers for use in nanoparticle drug delivery systems prepared by miniemulsion polymerisation - A multistep screening approach.

Astrid Hyldbakk, Yrr Mørch, Sofie Snipstad, Andreas K O Åslund, Geir Klinkenberg, Vu To Nakstad, Ane-Marit Wågbø, Ruth Schmid, Peter P Molesworth

Abstract read
In one paragraph

Article in International journal of pharmaceutics: X, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Astrid HyldbakkDepartment of Biotechnology and Nanomedicine, SINTEF Industry, Trondheim, Norway.
Yrr MørchDepartment of Biotechnology and Nanomedicine, SINTEF Industry, Trondheim, Norway.
Sofie SnipstadDepartment of Biotechnology and Nanomedicine, SINTEF Industry, Trondheim, Norway.
Andreas K O ÅslundDepartment of Biotechnology and Nanomedicine, SINTEF Industry, Trondheim, Norway.
Geir KlinkenbergDepartment of Biotechnology and Nanomedicine, SINTEF Industry, Trondheim, Norway.
Vu To NakstadDepartment of Biotechnology and Nanomedicine, SINTEF Industry, Trondheim, Norway.
Ane-Marit WågbøDepartment of Biotechnology and Nanomedicine, SINTEF Industry, Trondheim, Norway.
Ruth SchmidDepartment of Biotechnology and Nanomedicine, SINTEF Industry, Trondheim, Norway.
Peter P MolesworthDepartment of Biotechnology and Nanomedicine, SINTEF Industry, Trondheim, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Poly (alkyl cyanoacrylate) (PACA) polymeric nanoparticles (NPs) are promising drug carriers in drug delivery. However, the selection of commercially available alkyl cyanoacrylate (ACA) monomers is limited, because most monomers were designed for use in medical and industrial glues and later repurposed for drug encapsulation. This study therefore aimed to seek out novel ACA materials for use in NP systems using a toxicity led screening approach. A multistep strategy, including cytotoxicity screening of alcohols as degradation products of PACA (44 alcohols), NPs (14 polymers), and a final

Indexed as

CabazitaxelDrug deliveryNanoparticle characterisationPoly(alkyl cyanoacrylate) nanoparticlesToxicity screening

Identifiers

PMID35898812
PMCPMC9310130

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.