Evidence map›Paper›PMID 35898722›Full record

ArticleBrain communications2022

Long-term structural brain changes in adult rats after mild ischaemic stroke.

Warda Syeda, Charlotte M Ermine, Mohamed Salah Khilf, David Wright, Vanessa H Brait, Jess Nithianantharajah, Scott Kolbe, Leigh A Johnston, Lachlan H Thompson, Amy Brodtmann

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Warda SyedaThe Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.ORCID https://orcid.org/0000-0001-6294-622X
Charlotte M ErmineThe Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.ORCID https://orcid.org/0000-0003-4726-1120
Mohamed Salah KhilfThe Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.
David WrightDepartment of Neuroscience, Monash University, Clayton, Australia.ORCID https://orcid.org/0000-0002-7535-8651
Vanessa H BraitThe Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.
Jess NithianantharajahThe Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.
Scott KolbeDepartment of Neuroscience, Monash University, Clayton, Australia.
Leigh A JohnstonThe Melbourne Brain Centre Imaging Unit, The University of Melbourne, Parkville, Victoria, Australia.
Lachlan H ThompsonThe Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.ORCID https://orcid.org/0000-0003-2632-0304
Amy BrodtmannThe Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.
Florey Institute of Neuroscience and Mental Health · AUMonash University · AUThe University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preclinical studies of remote degeneration have largely focused on brain changes over the first few days or weeks after stroke. Accumulating evidence suggests that neurodegeneration occurs in other brain regions remote to the site of infarction for months and even years following ischaemic stroke. Brain atrophy appears to be driven by both axonal degeneration and widespread brain inflammation. The evolution and duration of these changes are increasingly being described in human studies, using advanced brain imaging techniques. Here, we sought to investigate long-term structural brain changes in a model of mild focal ischaemic stroke following injection of endothlin-1 in adult Long-Evans rats (

Indexed as

biomarkersDTIrodent stroketensor-based morphometryvolumetric MRI

Identifiers

PMID35898722
PMCPMC9309495
OpenAlexW4286559713

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.