ReviewFrontiers in neuroscience2022
Involvement of White Matter Language Tracts in Glioma: Clinical Implications, Operative Management, and Functional Recovery After Injury.
Review in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Connectome-guided glioma resection: a systematic review of white matter tract preservation and postoperative neurocognition.Neurosurgical review · 2026Pooled it
- Article
- Resting-State vs. Task-Based Functional Magnetic Resonance Imaging in Neurosurgical Planning: A Narrative Review of Clinical Applications.Biomedicines · 2026Review
- Unlocking the mind: brain mapping for the exploratory quest of functional and cognitive networks in awake neurosurgery.Neurosurgical review · 2026Article
- Separating the forest from the palm trees: Individual variation in a presurgical language mapping task.NeuroImage. Clinical · 2026Article
- Free water elimination tractometry reveals local and remote white matter alterations in diffuse gliomas.Journal of neuro-oncology · 2025Article
- EGFR Amplification in Diffuse Glioma and Its Correlation to Language Tract Integrity.Diagnostics (Basel, Switzerland) · 2025Article
- Neuroradiological Evaluation of Anatomo-Morphometric Arcuate Fascicle Modifications According to Different Brain Tumor Histotypes: An Italian Multicentric Study.Brain sciences · 2025Article
- Quantitative evaluation of neuroradiological and morphometric alteration of inferior Fronto-Occipital Fascicle across different brain tumor histotype: an Italian multicentric study.Acta neurochirurgica · 2025Article
- Language neuroscience in the operating room: neurosurgical considerations for multilingual brain tumor patients.Frontiers in oncology · 2025Review
- Low-grade gliomas do not grow along white matter tracts: evidence from quantitative imaging.Brain communications · 2025Article
- Attenuation coefficient as a tool to detect changes in the white matter of the rat brain caused by different types of gliomas and irradiation.Biomedical optics express · 2024Article
- Radiogenomics as an Integrated Approach to Glioblastoma Precision Medicine.Current oncology reports · 2024Review
- Delineation of three-dimensional tumor margins based on normalized absolute difference mapping via volumetric optical coherence tomography.Scientific reports · 2024Article
- Predictors for delayed awakening in adult glioma patients receiving awake craniotomy under monitored anesthesia care.Journal of neuro-oncology · 2023Article
- Multiparametric mapping of white matter reorganizations in patients with frontal glioma-related epilepsy.CNS neuroscience & therapeutics · 2023Article
- Review
- The combination of radiomics features and VASARI standard to predict glioma grade.Frontiers in oncology · 2023Article
- Large-scale brain networks and intra-axial tumor surgery: a narrative review of functional mapping techniques, critical needs, and scientific opportunities.Frontiers in human neuroscience · 2023Review
- The Role of Extra-Operative Cortical Stimulation and Mapping in the Surgical Management of Intracranial Gliomas.Brain sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
To achieve optimal survival and quality of life outcomes in patients with glioma, the extent of tumor resection must be maximized without causing injury to eloquent structures. Preservation of language function is of particular importance to patients and requires careful mapping to reveal the locations of cortical language hubs and their structural and functional connections. Within this language network, accurate mapping of eloquent white matter tracts is critical, given the high risk of permanent neurological impairment if they are injured during surgery. In this review, we start by describing the clinical implications of gliomas involving white matter language tracts. Next, we highlight the advantages and limitations of methods commonly used to identify these tracts during surgery including structural imaging techniques, functional imaging, non-invasive stimulation, and finally, awake craniotomy. We provide a rationale for combining these complementary techniques as part of a multimodal mapping paradigm to optimize postoperative language outcomes. Next, we review local and long-range adaptations that take place as the language network undergoes remodeling after tumor growth and surgical resection. We discuss the probable cellular mechanisms underlying this plasticity with emphasis on the white matter, which until recently was thought to have a limited role in adults. Finally, we provide an overview of emerging developments in targeting the glioma-neuronal network interface to achieve better disease control and promote recovery after injury.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.