Evidence map›Paper›PMID 35898274›Full record

ArticleFrontiers in cardiovascular medicine2022

Case Report: Steroid-Responsive Takotsubo Cardiomyopathy Associated With Cytokine Storm and Obstructive Shock.

Brent Gudenkauf, Michael R Goetsch, Rachit M Vakil, Oscar Cingolani, Luigi Adamo

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. The Immunology of Takotsubo Syndrome.Frontiers in immunology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Brent GudenkaufDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Michael R GoetschDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Rachit M VakilDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Oscar CingolaniDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Luigi AdamoDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

Myocardial-associated B lymphocytes and inflammatory injuryR01HL160716 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ADAMO, LUIGI · 2022 to 2025
$1.9M
Phenotype, dynamics and activation of myocardial B lymphocytes in response toischemia/reperfusion injuryK08HL145108 · NHLBI · WASHINGTON UNIVERSITY · PI ADAMO, LUIGI · 2019 to 2023
$753k
NHLBI NIH HHS K08 HL145108NHLBI NIH HHS R01 HL160716
6 · The paper itself

Abstract

A growing body of evidence suggests that inflammation may play a key role in the development of Takotsubo stress cardiomyopathy. Here, we report the case of a 63-year-old woman who presented with chest pain and was diagnosed with this cardiomyopathy. After an initial improvement, the patient experienced a systemic inflammatory response of unclear origin and deteriorated rapidly into obstructive shock. Her presentation was considered consistent with cytokine storm. She was, therefore, treated with steroids with rapid improvement in her clinical picture. She relapsed after the taper. Endomyocardial biopsy soon after initiation of pulse dose steroids showed macrophage and lymphocytic infiltration. This case highlights the potential intimate connection between systemic inflammatory response and Takotsubo stress cardiomyopathy and contributes to the evolving understanding of inflammation in the pathogenesis of this disease.

Indexed as

cytokine stormheart failureobstructive shockstress cardiomyopathyTakotsubo stress cardiomyopathy

Identifiers

PMID35898274
PMCPMC9309717
OpenAlexW4285005727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.