Evidence map›Paper›PMID 35897926›Full record

ArticleMolecules (Basel, Switzerland)2022

NMR Assignments of Six Asymmetrical N-Nitrosamine Isomers Determined in an Active Pharmaceutical Ingredient by DFT Calculations.

Hao-Yue Guan, Yu-Fei Feng, Bai-Hao Sun, Jian-Zhao Niu, Qing-Sheng Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hao-Yue GuanChemical Drugs Control Institute of China National Institutes for Food and Drug Control (NIFDC), No. 2 Tian Tan Xi Li Street, Dong Cheng District, Beijing 100050, China.
Yu-Fei FengChemical Drugs Control Institute of China National Institutes for Food and Drug Control (NIFDC), No. 2 Tian Tan Xi Li Street, Dong Cheng District, Beijing 100050, China.
Bai-Hao SunChemical Drugs Control Institute of China National Institutes for Food and Drug Control (NIFDC), No. 2 Tian Tan Xi Li Street, Dong Cheng District, Beijing 100050, China.
Jian-Zhao NiuChemical Drugs Control Institute of China National Institutes for Food and Drug Control (NIFDC), No. 2 Tian Tan Xi Li Street, Dong Cheng District, Beijing 100050, China.
Qing-Sheng ZhangChemical Drugs Control Institute of China National Institutes for Food and Drug Control (NIFDC), No. 2 Tian Tan Xi Li Street, Dong Cheng District, Beijing 100050, China.

Funding

National Major Scientific And Technological Special Project for "Significant New Drugs Development" 2017zx09101001
6 · The paper itself

Abstract

N-nitrosamines, which are well-known pro-mutagens, are found in drugs, pickled food and tobacco. Therefore, controlling their concentrations is very important. When an HPLC, GC or NMR analysis is conducted to investigate certain asymmetrical N-nitrosamines, two sets of signals attributed to the asymmetric N-nitrosamine isomers are usually observed. However, few reports on the NMR assignment of asymmetrical N-nitrosamine isomers have been published. In this study, we investigated the NMR assignments of the

Indexed as

NitrosaminesDensity Functional TheoryIsomerismMagnetic Resonance SpectroscopyPharmaceutical PreparationsNitrosaminesPharmaceutical Preparationsasymmetrical N-nitrosaminesdensity functional theory calculationisomersNMR assignmentvariable temperature 1H-NMR experiments

Identifiers

PMID35897926
PMCPMC9331877

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.