Evidence map›Paper›PMID 35897821›Full record

ArticleInternational journal of molecular sciences2022

Myeloperoxidase as a Marker to Differentiate Mouse Monocyte/Macrophage Subsets.

Cody J Gurski, Bonnie N Dittel

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Journal of inflammation research · 2026
    Article
  5. Article
  6. Article
  7. Pulmonary fibrosis: from mechanisms to therapies.Journal of translational medicine · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Cody J GurskiVersiti Blood Research Institute, Milwaukee, WI 53226, USA.
Bonnie N DittelVersiti Blood Research Institute, Milwaukee, WI 53226, USA.ORCID 0000-0003-4275-2457
Medical College of Wisconsin · USVersiti Blood Center of Wisconsin · US

Funding

Development of a B Cell TherapeuticR01AI160244 · NIAID · VERSITI WISCONSIN, INC. · PI DITTEL, BONNIE N · 2020 to 2024
$3.4M
The Role of B Cells in Regulating AutoimmunityR01AI069358 · NIAID · VERSITI WISCONSIN, INC. · PI DITTEL, BONNIE N · 2008 to 2012
$2.0M
NIAID NIH HHS R01 AI069358NIAID NIH HHS R01 AI160244NIH HHS R01AI160244-01
6 · The paper itself

Abstract

Macrophages are present in every tissue in the body and play essential roles in homeostasis and host defense against microorganisms. Some tissue macrophages derive from the yolk sac/fetal liver that populate tissues for life. Other tissue macrophages derive from monocytes that differentiate in the bone marrow and circulate through tissues via the blood and lymphatics. Circulating monocytes are very plastic and differentiate into macrophages with specialized functions upon entering tissues. Specialized monocyte/macrophage subsets have been difficult to differentiate based on cell surface markers. Here, using a combination of "pan" monocyte/macrophage markers and flow cytometry, we asked whether myeloperoxidase (MPO) could be used as a marker of pro-inflammatory monocyte/macrophage subsets. MPO is of interest because of its potent microbicidal activity. In wild-type SPF housed mice, we found that MPO

Indexed as

MonocytesPeroxidaseAnimalsBiomarkersLeukocyte CountMacrophagesMiceBiomarkersPeroxidasemacrophagemonocytemyeloperoxidase

Identifiers

PMID35897821
PMCPMC9330004
OpenAlexW4288069229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.