Evidence map›Paper›PMID 35897689›Full record

ArticleInternational journal of molecular sciences2022

Chemokine CXCL10 Modulates the Tumor Microenvironment of Fibrosis-Associated Hepatocellular Carcinoma.

Elisa F Brandt, Maike Baues, Theresa H Wirtz, Jan-Niklas May, Petra Fischer, Anika Beckers, Björn-Carsten Schüre, Hacer Sahin, Christian Trautwein, Twan Lammers and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Elisa F BrandtDepartment of Internal Medicine III, RWTH Aachen University, 52074 Aachen, Germany.
Maike BauesInstitute for Experimental Molecular Imaging, University Hospital RWTH Aachen, 52074 Aachen, Germany.ORCID 0000-0002-1637-2808
Theresa H WirtzDepartment of Internal Medicine III, RWTH Aachen University, 52074 Aachen, Germany.
Jan-Niklas MayInstitute for Experimental Molecular Imaging, University Hospital RWTH Aachen, 52074 Aachen, Germany.ORCID 0000-0003-0327-6267
Petra FischerDepartment of Internal Medicine III, RWTH Aachen University, 52074 Aachen, Germany.
Anika BeckersDepartment of Internal Medicine III, RWTH Aachen University, 52074 Aachen, Germany.
Björn-Carsten SchüreInstitute for Experimental Molecular Imaging, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Hacer SahinDepartment of Internal Medicine III, RWTH Aachen University, 52074 Aachen, Germany.
Christian TrautweinDepartment of Internal Medicine III, RWTH Aachen University, 52074 Aachen, Germany.
Twan LammersInstitute for Experimental Molecular Imaging, University Hospital RWTH Aachen, 52074 Aachen, Germany.ORCID 0000-0002-1090-6805
Marie-Luise BerresDepartment of Internal Medicine III, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0002-8009-948X
RWTH Aachen University · DE

Funding

Deutsche Forschungsgemeinschaft 36842431Deutsche Forschungsgemeinschaft 403224013Federal Ministry of Education and Research 031L0041German Cancer Aid 40111221
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) constitutes a devastating health burden. Recently, tumor microenvironment-directed interventions have profoundly changed the landscape of HCC therapy. In the present study, the function of the chemokine CXCL10 during fibrosis-associated hepatocarcinogenesis was analyzed with specific focus on its impact in shaping the tumor microenvironment. C57BL/6J wild type (WT) and

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsAnimalsCarcinogenesisChemokine CXCL10FibrosisMiceMice, Inbred C57BLTumor MicroenvironmentChemokine CXCL10angiogenesischemokine/chemokine receptor networkCXCL10hepatocellular carcinomatumor-associated immune responsetumor cell proliferationtumor microenvironment

Identifiers

PMID35897689
PMCPMC9329882
OpenAlexW4287010182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.