Evidence map›Paper›PMID 35897688›Full record

ArticleInternational journal of molecular sciences2022

New Hyaluronic Acid from Plant Origin to Improve Joint Protection-An In Vitro Study.

Rebecca Galla, Sara Ruga, Silvio Aprile, Sara Ferrari, Arianna Brovero, Giorgio Grosa, Claudio Molinari, Francesca Uberti

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
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  4. Article
  5. A Combined Probiotic-International journal of molecular sciences · 2026
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  6. Nutraceutical Effects ofNutrients · 2026
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  9. Neuroprotective Pathway Modulation by a NovelInternational journal of molecular sciences · 2025
    Article
  10. Combined Effects of Diosmin, Hesperidin,International journal of molecular sciences · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Non-Animal Hyaluronic Acid fromFoods (Basel, Switzerland) · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Rebecca GallaLaboratory of Physiology, Department of Translational Medicine, University of Piemonte Orientale, Via Solaroli 17, 28100 Novara, Italy.
Sara RugaLaboratory of Physiology, Department of Translational Medicine, University of Piemonte Orientale, Via Solaroli 17, 28100 Novara, Italy.
Silvio AprileDipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy.ORCID 0000-0003-4804-9543
Sara FerrariLaboratory of Physiology, Department of Translational Medicine, University of Piemonte Orientale, Via Solaroli 17, 28100 Novara, Italy.
Arianna BroveroLaboratory of Physiology, Department of Translational Medicine, University of Piemonte Orientale, Via Solaroli 17, 28100 Novara, Italy.
Giorgio GrosaDipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy.
Claudio MolinariDipartimento per lo Sviluppo Sostenibile e la Transizione Ecologica, University of Piemonte Orientale, 13100 Vercelli, Italy.
Francesca UbertiLaboratory of Physiology, Department of Translational Medicine, University of Piemonte Orientale, Via Solaroli 17, 28100 Novara, Italy.ORCID 0000-0001-5751-270X
Università degli Studi del Piemonte Orientale “Amedeo Avogadro” · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn recent decades, hyaluronic acid (HA) has attracted great attention as a new treatment option for osteoarthritis. Classical therapies are not able to stop the cartilage degeneration process nor do they favor tissue repair. Nowadays, it is accepted that high molecular weight HA can reduce inflammation by promoting tissue regeneration; therefore, the aim of this study was to verify the efficacy of a new high molecular weight HA of plant origin (called GreenIuronic

methodsThe bioavailability of GreenIuronic

resultsOur data demonstrated that GreenIuronic

conclusionAccording to our results, this new form of HA appears to be well absorbed and distributed to chondrocytes, preserving their biological activities. Therefore, the oral administration of GreenIuronic

Indexed as

Cartilage, ArticularOsteoarthritisCartilageChondrocytesHumansHyaluronic AcidInflammationHyaluronic Acidcartilage inflammationchondrocyteshigh molecular weight hyaluronic acidintestinal absorptionosteoarthritistissue degradation

Identifiers

PMID35897688
PMCPMC9332867
OpenAlexW4287009872

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.