Evidence map›Paper›PMID 35897654›Full record

ArticleInternational journal of molecular sciences2022

Clinical and Functional Study of a De Novo Variant in the PVP Motif of Kv1.1 Channel Associated with Epilepsy, Developmental Delay and Ataxia.

Giorgia Dinoi, Michael Morin, Elena Conte, Hagar Mor Shaked, Maria Antonietta Coppola, Maria Cristina D'Adamo, Orly Elpeleg, Antonella Liantonio, Inbar Hartmann, Annamaria De Luca and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Giorgia DinoiDepartment of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", 70125 Bari, Italy.
Michael MorinDepartment of Physics, Université de Montréal, Montreal, QC H3C 3J7, Canada.
Elena ConteDepartment of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", 70125 Bari, Italy.ORCID 0000-0001-8571-5125
Hagar Mor ShakedDepartment of Genetics, Hadassah Medical Center, Jerusalem 91120, Israel.
Maria Antonietta CoppolaDepartment of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", 70125 Bari, Italy.
Maria Cristina D'AdamoDepartment of Medicine and Surgery, LUM University, 70010 Casamassima, Italy.ORCID 0000-0002-6758-6064
Orly ElpelegDepartment of Genetics, Hadassah Medical Center, Jerusalem 91120, Israel.
Antonella LiantonioDepartment of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", 70125 Bari, Italy.
Inbar HartmannPediatric Neurology Clinic, Shamir Medical Center (Assaf Harofeh), Zerifin 7033001, Israel.
Annamaria De LucaDepartment of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", 70125 Bari, Italy.ORCID 0000-0002-5652-7341
Rikard BlunckDepartment of Physics, Université de Montréal, Montreal, QC H3C 3J7, Canada.ORCID 0000-0003-4484-2907
Angelo RussoChild Neurology Unit, IRCCS, Institute of Neurological Sciences of Bologna, 40139 Bologna, Italy.ORCID 0000-0002-0322-2640
Paola ImbriciDepartment of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", 70125 Bari, Italy.ORCID 0000-0001-9140-5350
University of Bari Aldo Moro · ITHadassah Medical Center · ILUniversité de Montréal · CAAssaf Harofeh Medical Center · ILInstitute of Neurological Sciences · ITLibera Università Maria SS. Assunta · IT

Funding

Canadian Institutes for Health Research (CIHR) Grant PJT-169160Fondi Ateneo - Università di Bari 2017-2018Natural Sciences and Engineering Research Council (NSERC) Grant RGPIN-2017-06871
6 · The paper itself

Abstract

Mutations in the

Indexed as

EpilepsyKv1.1 Potassium ChannelAcetazolamideAtaxiaHEK293 CellsHumansMutationPotassiumAcetazolamideKv1.1 Potassium ChannelPotassiumataxiaepilepsyKCNA1lacosamidemolecular dynamicspatch clampPVP motif

Identifiers

PMID35897654
PMCPMC9331732
OpenAlexW4286587353

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.