Evidence map›Paper›PMID 35897556›Full record

ArticleMaterials (Basel, Switzerland)2022

An Electroconductive, Thermosensitive, and Injectable Chitosan/Pluronic/Gold-Decorated Cellulose Nanofiber Hydrogel as an Efficient Carrier for Regeneration of Cardiac Tissue.

Hajar Tohidi, Nahid Maleki-Jirsaraei, Abdolreza Simchi, Fatemeh Mohandes, Zahra Emami, Lorenzo Fassina, Fabio Naro, Bice Conti, Federica Barbagallo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Hajar TohidiDepartment of Physics and Chemistry, Alzahra University, Vanak Village Street, Tehran 19938 93973, Iran.
Nahid Maleki-JirsaraeiDepartment of Physics and Chemistry, Alzahra University, Vanak Village Street, Tehran 19938 93973, Iran.ORCID 0000-0002-3022-641X
Abdolreza SimchiDepartment of Materials Science and Engineering, Sharif University of Technology, Azadi Avenue, Tehran 14588 89694, Iran.ORCID 0000-0002-9111-2977
Fatemeh MohandesDepartment of Materials Science and Engineering, Sharif University of Technology, Azadi Avenue, Tehran 14588 89694, Iran.ORCID 0000-0001-8005-1817
Zahra EmamiDepartment of Materials Science and Engineering, Sharif University of Technology, Azadi Avenue, Tehran 14588 89694, Iran.
Lorenzo FassinaDepartment of Electrical, Computer and Biomedical Engineering, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-5587-4632
Fabio NaroDepartment of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University, 00185 Rome, Italy.ORCID 0000-0003-0572-5900
Bice ContiDepartment of Drug Sciences, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-0034-2815
Federica BarbagalloDepartment of Experimental Medicine, Sapienza University, 00185 Rome, Italy.ORCID 0000-0002-2972-370X
Sharif University of Technology · IRAlzahra University · IRUniversity of Pavia · ITSapienza University of Rome · ITUniversità degli Studi di Enna Kore · IT

Funding

Iran National Science Foundation 95-S-48740Sharif University of Technology QA970816
6 · The paper itself

Abstract

Myocardial infarction is a major cause of death worldwide and remains a social and healthcare burden. Injectable hydrogels with the ability to locally deliver drugs or cells to the damaged area can revolutionize the treatment of heart diseases. Herein, we formulate a thermo-responsive and injectable hydrogel based on conjugated chitosan/poloxamers for cardiac repair. To tailor the mechanical properties and electrical signal transmission, gold nanoparticles (AuNPs) with an average diameter of 50 nm were physically bonded to oxidized bacterial nanocellulose fibers (OBC) and added to the thermosensitive hydrogel at the ratio of 1% w/v. The prepared hydrogels have a porous structure with open pore channels in the range of 50−200 µm. Shear rate sweep measurements demonstrate a reversible phase transition from sol to gel with increasing temperature and a gelation time of 5 min. The hydrogels show a shear-thinning behavior with a shear modulus ranging from 1 to 12 kPa dependent on gold concentration. Electrical conductivity studies reveal that the conductance of the polymer matrix is 6 × 10−2 S/m at 75 mM Au. In vitro cytocompatibility assays by H9C2 cells show high biocompatibility (cell viability of >90% after 72 h incubation) with good cell adhesion. In conclusion, the developed nanocomposite hydrogel has great potential for use as an injectable biomaterial for cardiac tissue regeneration.

Indexed as

electroactivegold-decorated cellulose nanofiberheart diseasesnanocompositesmart hydrogel

Identifiers

PMID35897556
PMCPMC9330822
OpenAlexW4287093078

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.