Evidence map›Paper›PMID 35897481›Full record

ArticleInternational journal of environmental research and public health2022

A Pilot Study on the Association of Lead, 8-Hydroxyguanine, and Malondialdehyde Levels in Opium Addicts' Blood Serum with Illicit Drug Use and Non-Addict Persons.

Farzaneh Allahdinian Hesaruiyeh, Saeed Rajabi, Mohadeseh Motamed-Jahromi, Mohammad Sarhadi, Michelle L Bell, Razieh Khaksefidi, Somayeh Sarhadi, Leili Mohammadi, Kamal Dua, Amin Mohammadpour and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Interpol review of forensic drug chemistry, 2022-2025.Forensic science international. Synergy · 2026
    Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 4 countries.

Farzaneh Allahdinian HesaruiyehDepartment of Toxicology, Faculty of Pharmacy, Shahreza Branch, Islamic Azad University, Shahreza P. O. Box 311-86145, Iran.
Saeed RajabiStudent Research Committee, School of Health, Shiraz University of Medical Sciences, Shiraz 71348-45794, Iran.ORCID 0000-0002-0082-104X
Mohadeseh Motamed-JahromiNursing School, Fasa University of Medical Science, Fasa 74616-86688, Iran.
Mohammad SarhadiCellular and Molecular Research Center, Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan 98167-43463, Iran.ORCID 0000-0002-3766-7664
Michelle L BellSchool of Forestry and Environmental Studies, Yale University, New Haven, CT 06520, USA.ORCID 0000-0002-3965-1359
Razieh KhaksefidiStudent Research Committee, School of Health, Shiraz University of Medical Sciences, Shiraz 71348-45794, Iran.
Somayeh SarhadiDepartment of Biology, Faculty of Sciences, Hamedan Branch, Islamic Azad University, Hamedan 15847-43311, Iran.
Leili MohammadiEnvironmental Health, Infectious Diseases and Tropical Medicine Research Center, Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan 98167-43463, Iran.
Kamal DuaCentre for Inflammation, Centenary Institute, Sydney, NSW 2050, Australia.ORCID 0000-0002-7507-1159
Amin MohammadpourStudent Research Committee, School of Health, Shiraz University of Medical Sciences, Shiraz 71348-45794, Iran.
Paolo MartellettiDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-6556-4128
Shiraz University of Medical Sciences · IRZahedan University of Medical Sciences · IRFasa University of Medical Sciences · IRIslamic Azad University of Hamedan · IRIslamic Azad University of Shahreza · IRSapienza University of Rome · ITUniversity of Technology Sydney · AUYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While a large body of literature has shown the health problems of illicit drug use, research is needed on how substance abuse impacts DNA damage and contaminants in blood, especially given Pb-contaminated opium. This pilot study aimed to evaluate the levels of lead (Pb), 8-hydroxy di-guanine (8-oxo-Gua), and malondialdehyde (MDA) in the blood serum of opium addicts and non-addict people. The current study is a case-control study with a cross-sectional design. A sample of 50 opium-addicted and non-addict adults were chosen for this study using convenience and random sampling methods. Participants were divided into two groups: addicts and non-addicts. The atomic absorption spectroscopy method was used to measure the quantity of Pb, and the Enzyme-Linked Immunosorbent Assay (ELISA) method was used to measure the amount of 8-oxo-Gua and MDA. The data were analyzed using an independent t-test. The results show that the amount of Pb in the blood serum of addicted women and men was higher than levels in non-addict men and women, for the study participants (

Indexed as

Illicit DrugsSubstance-Related DisordersAdultCase-Control StudiesCross-Sectional StudiesFemaleGuanineHumansLeadMaleMalondialdehydeOpiumPilot ProjectsSerum8-hydroxyguanineGuanineIllicit DrugsLeadMalondialdehydeOpium8-hydroxyguanineaddictsblood serumleadmalondialdehyde

Identifiers

PMID35897481
PMCPMC9368398
OpenAlexW4288041893

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.