Evidence map›Paper›PMID 35897312›Full record

SynthesisInternational journal of environmental research and public health2022

Telomere Length and Hearing Loss: A Two-Sample Mendelian Randomization.

Yun Liu, Shuangyan Liu, Jiarui Xin, Peiyi Qian, Shuli Guo, Xiaojun Xu, Dahui Wang, Lei Yang

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Yun LiuSchool of Public Health, Hangzhou Normal University, Hangzhou 310000, China.
Shuangyan LiuSchool of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Jiarui XinSchool of Public Health, Hangzhou Normal University, Hangzhou 310000, China.
Peiyi QianSchool of Public Health, Hangzhou Normal University, Hangzhou 310000, China.
Shuli GuoSchool of Public Health, Hangzhou Normal University, Hangzhou 310000, China.
Xiaojun XuSchool of Public Health, Hangzhou Normal University, Hangzhou 310000, China.
Dahui WangSchool of Public Health, Hangzhou Normal University, Hangzhou 310000, China.
Lei YangSchool of Public Health, Hangzhou Normal University, Hangzhou 310000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObservational studies have suggested that there may be an association between telomere length (TL) and hearing loss (HL). However, inferring causality from observational studies is subject to residual confounding effects, reverse causation, and bias. This study adopted a two-sample Mendelian randomization (MR) approach to evaluate the causal relationship between TL and increased risk of HL.

methodsA total of 16 single nucleotide polymorphisms (SNPs) associated with TL were identified from a genome-wide association study (GWAS) meta-analysis of 78,592 European participants and applied to our modeling as instrumental variables. Summary-level data for hearing loss (HL), age-related hearing loss (ARHL), and noise-induced hearing loss (NIHL) were obtained from the recent largest available GWAS and five MR analyses were used to investigate the potential causal association of genetically predicted TL with increased risk for HL, including the inverse-variance-weighted (IVW), weighted median, MR-Egger regression, simple mode, and weighted mode. In addition, sensitivity analysis, pleiotropy, and heterogeneity tests were also used to evaluate the robustness of our findings.

resultsThere was no causal association between genetically predicted TL and HL or its subtypes (by the IVW method, HL: odds ratio (OR) = 1.216,

conclusionThere was no clear causal relationship between shorter TLs and increased risk of HL or its subtypes in this dataset.

Indexed as

Hearing LossMendelian Randomization AnalysisGenome-Wide Association StudyHumansPolymorphism, Single NucleotideTelomereage-related hearing losscausal effecthearing lossMendelian randomizationnoise-induced hearing losstelomere length

Identifiers

PMID35897312
PMCPMC9330868

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.