ArticleThe Plant cell2022
Methylation of a MITE insertion in the MdRFNR1-1 promoter is positively associated with its allelic expression in apple in response to drought stress.
Article in The Plant cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 82 citations in OpenAlex.
- OsDUF1223 negatively regulates seedling drought tolerance and modulates nitrate-dependent root growth in rice.PLoS genetics · 2026Article
- Regulatory insights underlying apple to cold stress.Horticulture research · 2026Article
- Drought stress priming induces morphological adaptation and methylome changes in apple seedlings.BMC plant biology · 2026Article
- The TaMADS2-TaTBL21 Module Enhances Wheat Resistance to Stripe Rust by Activating TaGKL-Mediated Immunity.Plant biotechnology journal · 2026Article
- panHiTE: A comprehensive and accurate pipeline for TE detection in large-scale population genomes.Plant communications · 2026Article
- Genome-Wide Identification and Functional Analysis of DNA Methylation-Related Genes inPlants (Basel, Switzerland) · 2026Article
- Root-Specific Signal Modules Mediating Abiotic Stress Tolerance in Fruit Crops.Plants (Basel, Switzerland) · 2026Review
- Plant MITEs: miniature transposable elements with major impacts.Mobile DNA · 2025Review
- MITE Annotation and Landscape in 207 Plant Genomes Reveal Their Evolutionary Dynamics and Functional Roles.Molecular ecology resources · 2025Article
- Identification of PpTHE1, a cell wall integrity sensor regulating the increased duration of harvest window in slow-melting flesh peach, through the assembly of a chromosome-level reference genome of Prunus persica.Plant biotechnology journal · 2025Article
- An integrative multi-omics analysis of histone modifications and DNA methylation reveals the epigenomic landscape in apple under drought stress.Plant biotechnology journal · 2025Article
- Review
- Engineering saline-alkali-tolerant apple rootstocks by overexpressingMolecular breeding : new strategies in plant improvement · 2025Article
- MdDSK2a-Like-MdMTA Module Functions in Apple Cold Response via Regulating ROS Detoxification and Cell Wall Deposition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Engineering saline-alkali-tolerant apple rootstock by knocking down MdGH3 genes in M9-T337.Stress biology · 2025Article
- Physiologic, Genetic and Epigenetic Determinants of Water Deficit Tolerance in Fruit Trees.Plants (Basel, Switzerland) · 2025Review
- Pan-genome analysis reveals the evolution and diversity of Malus.Nature genetics · 2025Article
- Integrative analysis of genome-wide association studies of polyphenols in apple fruits identifies the MdDof2.4Horticulture research · 2025Article
- An InDel variant in the promoter of the NAC transcription factor MdNAC18.1 plays a major role in apple fruit ripening.The Plant cell · 2024Article
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16 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Miniature inverted-repeat transposable elements (MITEs) are widely distributed in the plant genome and can be methylated. However, whether DNA methylation of MITEs is associated with induced allelic expression and drought tolerance is unclear. Here, we identified the drought-inducible MdRFNR1 (root-type ferredoxin-NADP+ oxidoreductase) gene in apple (Malus domestica). MdRFNR1 plays a positive role in drought tolerance by regulating the redox system, including increasing NADP+ accumulation and catalase and peroxidase activities and decreasing NADPH levels. Sequence analysis identified a MITE insertion (MITE-MdRF1) in the promoter of MdRFNR1-1 but not the MdRFNR1-2 allele. MdRFNR1-1 but not MdRFNR1-2 expression was significantly induced by drought stress, which was positively associated with the MITE-MdRF1 insertion and its DNA methylation. The methylated MITE-MdRF1 is recognized by the transcriptional anti-silencing factors MdSUVH1 and MdSUVH3, which recruit the DNAJ domain-containing proteins MdDNAJ1, MdDNAJ2, and MdDNAJ5, thereby activating MdRFNR1-1 expression under drought stress. Finally, we showed that MdSUVH1 and MdDNAJ1 are positive regulators of drought tolerance. These findings illustrate the molecular roles of methylated MITE-MdRF1 (which is recognized by the MdSUVH-MdDNAJ complex) in induced MdRFNR1-1 expression as well as the drought response of apple and shed light on the molecular mechanisms of natural variation in perennial trees.
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