Evidence map›Paper›PMID 35897105›Full record

ArticlePediatric rheumatology online journal2022

Bone remodeling serum markers in children with systemic lupus erythematosus.

Sheng Hao, Jing Zhang, Bingxue Huang, Dan Feng, Xiaoling Niu, Wenyan Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric rheumatology online journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sheng HaoDepartment of Nephrology, Rheumatology and Immonology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, 200062, China.
Jing ZhangDepartment of Nephrology, Rheumatology and Immonology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, 200062, China.
Bingxue HuangDepartment of Nephrology, Rheumatology and Immonology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, 200062, China.
Dan FengDepartment of Nephrology, Rheumatology and Immonology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, 200062, China.
Xiaoling NiuDepartment of Nephrology, Rheumatology and Immonology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, 200062, China.
Wenyan HuangDepartment of Nephrology, Rheumatology and Immonology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, 200062, China. huangwenyan@sjtu.edu.cn.
Shanghai Children's Hospital · CNShanghai Jiao Tong University · CN

Funding

Medical and industrial cross research fund of Shanghai Jiao Tong University YG2021QN118Natural Science Foundation of Shanghai Children's Hospital NO.2020YGZM01
6 · The paper itself

Abstract

indroductionSLE is an autoimmune multisystem disease. Glucocorticoid is an irreplaceable medication for SLE. Glucocorticoid and inflammatory mediators impact bone remodeling by OPG/RANKL/RANK signal system, which could lead to osteoporosis. Our aim is to detect the expression of RANKL/OPG in children with SLE, and to preliminarily explore the changes of bone remodeling serum markers in children with SLE.

methodsSerum RANKL and OPG of 40 children with SLE and healthy children were detected by ELISA, while 25(OH)VitD

resultsSerum RANKL concentrations in SLE group were significantly higher than health group (9.82 ± 7.20 vs. 6.80 ± 4.35 pg/ml and 0.081 ± 0.072 vs. 0.042 ± 0.034, P < 0.05) respectively, and the concentrations of OPG and 25(OH)VitD

conclusionLow levels of vitamin D

Indexed as

Autoimmune DiseasesLupus Erythematosus, SystemicBiomarkersBone DensityBone RemodelingChildGlucocorticoidsHumansOsteoprotegerinBiomarkersGlucocorticoidsOsteoprotegerinGlucocorticoidOsteoprotegerinPediatric systemic lupus erythematosusReceptor activator of nuclear factor-κB ligandVitamin D

Identifiers

PMID35897105
PMCPMC9327424
OpenAlexW4288724881

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.