Evidence map›Paper›PMID 35897081›Full record

Trial reportTrials2022

Ketamine for acute pain after trauma: the KAPT randomized controlled trial.

Thaddeus J Puzio, James Klugh, Michael W Wandling, Charles Green, Julius Balogh, Samuel J Prater, Christopher T Stephens, Paulina B Sergot, Charles E Wade, Lillian S Kao and 1 more

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04129086 phase4completednot on this map

Ketamine for Acute Pain After Trauma: KAPT Trial

TypeinterventionalSponsorThe University of Texas Health Science Center, HoustonRan2020 to 2022Enrolled305ConditionsTrauma Injury, Pain, Opioid UseArmsKetamine plus usual care, Usual Care
NCT07059429 nacompletednot on this mapstarted 2025, after this paper: background citation

Randomized Controlled Study of Ketamine Administration for Postoperative Pain Management in Patients Undergoing Knee Arthroplasty,

TypeinterventionalSponsorState Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of RussiaRan2025 to 2026Enrolled100ConditionsKnee Arthroplasty, Postoperative Pain, Pain Management, AnalgesiaArmsKetamine, Standard Analgesia
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Thaddeus J PuzioDepartment of Surgery, McGovern Medical School at UTHealth, The University of Texas, Houston, TX, USA. Thaddeus.J.Puzio@uth.tmc.edu.ORCID http://orcid.org/0000-0003-4150-5956
James KlughDepartment of Surgery, McGovern Medical School at UTHealth, The University of Texas, Houston, TX, USA.
Michael W WandlingDepartment of Surgery, McGovern Medical School at UTHealth, The University of Texas, Houston, TX, USA.
Charles GreenCenter for Clinical Research and Evidence Based Medicine, McGovern Medical School at UTHealth, Houston, TX, USA.
Julius BaloghDepartment of Anesthesia, University of Arkansas for Medical Sciences, Little Rock, USA.
Samuel J PraterDepartment of Emergency Medicine, The University of Texas Medical Center at Houston, Houston, USA.
Christopher T StephensDepartment of Anesthesiology, McGovern Medical School at UTHealth, Houston, TX, USA.
Paulina B SergotDepartment of Emergency Medicine, The University of Texas Medical Center at Houston, Houston, USA.
Charles E WadeCenter for Translational Injury Research, Department of Surgery, McGovern Medical School at UTHealth, Houston, TX, USA.
Lillian S KaoDepartment of Surgery, McGovern Medical School at UTHealth, The University of Texas, Houston, TX, USA.
John A HarvinDepartment of Surgery, McGovern Medical School at UTHealth, The University of Texas, Houston, TX, USA.
The University of Texas Health Science Center · USTexas Medical Center · USCenter for Clinical Research (United States) · USThe University of Texas Health Science Center at Houston · USUniversity of Arkansas for Medical Sciences · US

Funding

Convalescent Plasma to Limit Coronavirus Associated ComplicationsUL1TR003167 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARP, DANIEL D, MCPHERSON, DAVID D · 2019 to 2023
$45.3M
NCATS NIH HHS UL1 TR003167University of Texas McGovern Medical School UL1TR003167
6 · The paper itself

Abstract

backgroundEvidence for effective pain management and opioid minimization of intravenous ketamine in elective surgery has been extrapolated to acutely injured patients, despite limited supporting evidence in this population. This trial seeks to determine the effectiveness of the addition of sub-dissociative ketamine to a pill-based, opioid-minimizing multi-modal pain regimen (MMPR) for post traumatic pain.

methodsThis is a single-center, parallel-group, randomized, controlled comparative effectiveness trial comparing a MMPR to a MMPR plus a sub-dissociative ketamine infusion. All trauma patients 16 years and older admitted following a trauma which require intermediate (IMU) or intensive care unit (ICU) level of care are eligible. Prisoners, patients who are pregnant, patients not expected to survive, and those with contraindications to ketamine are excluded from this study. The primary outcome is opioid use, measured by morphine milligram equivalents (MME) per patient per day (MME/patient/day). The secondary outcomes include total MME, pain scores, morbidity, lengths of stay, opioid prescriptions at discharge, and patient centered outcomes at discharge and 6 months. DISCUSSION: This trial will determine the effectiveness of sub-dissociative ketamine infusion as part of a MMPR in reducing in-hospital opioid exposure in adult trauma patients. Furthermore, it will inform decisions regarding acute pain strategies on patient centered outcomes.

trial registrationThe Ketamine for Acute Pain Management After Trauma (KAPT) with registration # NCT04129086 was registered on October 16, 2019.

Indexed as

Acute PainKetamineAdultAnalgesicsAnalgesics, OpioidHumansPain MeasurementPostoperative PainAnalgesicsAnalgesics, OpioidKetamineAnalgesiaKetamineMultimodal pain control

Identifiers

PMID35897081
PMCPMC9326146
OpenAlexW4288724470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.