Evidence map›Paper›PMID 35897080›Full record

ArticleTrials2022

Protocol for a multi-center randomized controlled trial to evaluate the benefits of exercise incentives and corticosteroid injections in osteoarthritis of the knee (MOVE-OK).

William Leach, Caleigh Doherty, Marianna Olave, Bryant R England, Katherine Wysham, Gail Kerr, Mercedes Quinones, Alexis Ogdie, Dan White, Tuhina Neogi and 2 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05035810 (A Pragmatic Trial to Determine the Benefit of Behaviorally Enhanced Exercise Incentives and Corticosteroid Injections in Osteoarthritis of the Knee), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05035810 phase3active not recruitingnot on this map

A Pragmatic Trial to Determine the Benefit of Behaviorally Enhanced Exercise Incentives and Corticosteroid Injections in Osteoarthritis of the Knee

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2022 to 2025Enrolled221ConditionsOsteoarthritis of the KneeArmsSocial Incentives and Gamification to Promote Exercise, Corticosteroid Injection given in A-B order, No Social Incentive applied, Procedure: Corticosteroid Injection given in B-A order
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Teaming up to overcome challenges toward translation of new therapeutics for osteoarthritis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

William LeachCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
Caleigh DohertyPerelman School of Medicine, University of Pennsylvania, 5th Floor White Building, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Marianna OlaveCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
Bryant R EnglandMedicine Service, VA Nebraska-Western Iowa Health Care System and Department of Internal Medicine, Division of Rheumatology & Immunology, University of Nebraska Medical Center, Omaha, NE, USA.
Katherine WyshamVA Puget Sound Health Care System and University of Washington, Seattle, WA, USA.
Gail KerrWashington DC VA Medical Center, Washington, D.C, USA.
Mercedes QuinonesWashington DC VA Medical Center, Washington, D.C, USA.
Alexis OgdiePerelman School of Medicine, University of Pennsylvania, 5th Floor White Building, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Dan WhiteUniversity of Delaware, Newark, DE, USA.
Tuhina NeogiBoston University School of Medicine, Boston, MA, USA.
Carla R ScanzelloCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
Joshua F BakerCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA. Joshua.baker@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0003-0799-7563
Philadelphia VA Medical Center · USUniversity of Pennsylvania · USWashington DC VA Medical Center · USUniversity of Delaware · USUniversity of Washington · USVA Nebraska Western Iowa Health Care System · US

Funding

Research and Evaluation Support Core Unit (RESCU Core)P30AR072571 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2019 to 2026
$6.9M
A Pragmatic Trial to Determine the Benefit of Behaviorally Enhanced Exercise Incentives and Corticosteroid Injections in Osteoarthritis of the KneeI01RX003644 · VA · PHILADELPHIA VA MEDICAL CENTER · PI BAKER, JOSHUA F. · 2022 to 2025
–
CSRD VA I01 CX001703NIAMS NIH HHS P30 AR072571RRD VA I01 RX003644RRD VA I21 RX003157
6 · The paper itself

Abstract

backgroundKnee osteoarthritis (KOA) is a high-priority problem among the aging population. While exercise has been shown to be beneficial in management of the disease, scalable and low-cost interventions to improve exercise in this population are lacking. Recent controversy over the value of corticosteroid injections for palliation has also arisen. Therefore, we designed a randomized, double-blind, placebo-controlled clinical trial with a 2-period crossover design to study (1) behavioral incentives to promote exercise and (2) corticosteroid injections to reduce pain and improve function in patients with KOA when compared to lidocaine only.

methodsThe study design is a pragmatic factorial and crossover randomized clinical trial. Patients with KOA who are deemed eligible by their provider to receive knee injections and are able to walk without assistive devices will be recruited from clinical practices at four sites within the Veterans Affairs (VA) Health System in the USA. In total, 220 participants will be randomized to receive social incentives with gamification (i.e., incorporation of game elements) to promote exercise and compared to controls that receive a Fitbit but no incentive. Each patient will also be assigned to receive a blinded corticosteroid injection and a lidocaine-only injection in random order. The primary outcomes are the change in average daily step counts from baseline and the change in Knee Osteoarthritis Outcome Score (KOOS) from baseline. The study team will continuously collect step count, heart rate, and sleep data using activity monitors and patient-reported outcomes using the Way to Health (WTH) platform at two four-week intervals over eight months of follow-up. Mixed effects regression incorporating all available data points will be used for analysis. DISCUSSION: The "Marching on for Veterans with Osteoarthritis of the Knee" (MOVE-OK) trial will take a pragmatic approach to evaluate (1) whether incentives based on behaviorally enhanced gamification can improve physical activity in this patient population and (2) whether corticosteroids injections reduce pain and disability in patients with KOA. Results of this trial will help to direct clinical practice and inform management guidelines.

trial registrationClinicalTrials.gov NCT05035810 . Registered on 5 September 2021.

Indexed as

Osteoarthritis, KneeVeteransAdrenal Cortex HormonesAgedExerciseHumansLidocaineMulticenter Studies as TopicPainPragmatic Clinical Trials as TopicRandomized Controlled Trials as TopicTreatment OutcomeAdrenal Cortex HormonesLidocaineBehavioral incentivesCorticosteroid injectionsCrossover designExerciseMulti-centerOsteoarthritis of the kneeRandomized controlled trial

Identifiers

PMID35897080
PMCPMC9327347
OpenAlexW4288060372

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.