ArticleNature2022
PI3K drives the de novo synthesis of coenzyme A from vitamin B5.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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57citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
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Who cites it
57 citing papers in PubMed, 93 citations in OpenAlex.
- Serum metabolic profiling analysis of Gitelman syndrome using untargeted metabolomics.Renal failure · 2026Article
- c-Myc-PANK3-EMT axis regulates the structure and function of intestinal barrier in ulcerative colitis.Journal of advanced research · 2026Article
- Fatty acid oxidation fuels mitochondrial respiration to drive epidermal stem cell fate and differentiation.Nature communications · 2026Article
- Metabolic-epigenetic reprogrammingActa pharmaceutica Sinica. B · 2026Article
- The transcription factor ZNF217 drives hepatocellular carcinoma progression by activating de novo lipid synthesis via FASN upregulation.Journal of cancer research and clinical oncology · 2026Article
- Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism.The FEBS journal · 2026Article
- A liquid chromatography-mass spectrometry method to quantify total Coenzyme A concentration and isotopic labeling.bioRxiv : the preprint server for biology · 2026Article
- Article
- Renal coenzyme A (CoA) production from VB5 fuels stem cell proliferation and tumor growth.Nature communications · 2026Article
- Article
- Application of untargeted plasma metabolomics and machine learning to construct a diagnostic model for hypertrophic cardiomyopathy: a case-control study.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Bone marrow stromal cells enhance multiple myeloma cells proliferation through regulating LncRNA OVAAL/ENPP1 axis.Open life sciences · 2026Article
- Nuclear accumulation of PANK4 in hippocampal astrocytes aggravates cuproptosis in association with mild cognitive impairment in aged mice.Frontiers in aging neuroscience · 2026Article
- The PI3K pathway is a downstream effector of NRF2 activation in the esophagus.Translational oncology · 2026Article
- Effects of Dietary Supplementation with Dihydromyricetin on Hindgut Microbiota and Metabolite Profiles in Dairy Cows.Microorganisms · 2025Article
- Article
- Genetic and Multi-Omics Insights Into Monocyte Pantothenate-Mediated Protection in Acute Respiratory Distress Syndrome.Journal of cellular and molecular medicine · 2025Article
- Pantothenate kinase 4 controls lipid synthesis for T-cell proliferation by modulating coenzyme A and glutaminolysis.Signal transduction and targeted therapy · 2025Article
- Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets.Cancer discovery · 2025Article
- Cellular pan-chain acyl-CoA profiling reveals SLC25A42/SLC25A16 in mitochondrial CoA import and metabolism.Nature metabolism · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 1 country.
Christian C Dibble *Department of Pathology, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. ccdibble@bidmc.harvard.edu.ORCID http://orcid.org/0000-0002-1122-9017
Samuel A Barritt *Department of Pathology, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3241-1272
Grace E PerryDepartment of Pathology, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0404-9237
Evan C LienDepartment of Pathology, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Renee C GeckDepartment of Pathology, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7812-7675
Sarah E DuBois-CoyneDepartment of Pathology, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
David BarteeChemical Biology Laboratory, National Cancer Institute, Frederick, MD, USA.ORCID http://orcid.org/0000-0001-8090-4242
Thomas T ZengeyaChemical Biology Laboratory, National Cancer Institute, Frederick, MD, USA.
Emily B CohenDepartment of Pathology, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Min YuanMass Spectrometry Core, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Benjamin D HopkinsDepartment of Genetics and Genomic Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-7970-6430
Jordan L MeierChemical Biology Laboratory, National Cancer Institute, Frederick, MD, USA.
John G ClohessyPreclinical Murine Pharmacogenetics Facility and Mouse Hospital, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5186-9775
John M AsaraMass Spectrometry Core, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Lewis C CantleyThe Sandra and Edward Meyer Cancer Center, Weill Medical College of Cornell University, New York, NY, USA.ORCID http://orcid.org/0000-0002-1298-7653
Alex TokerDepartment of Pathology, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. atoker@bidmc.harvard.edu.ORCID http://orcid.org/0000-0003-0723-4419
Beth Israel Deaconess Medical Center · USNational Cancer Institute · USCornell University · USIcahn School of Medicine at Mount Sinai · US
Funding
VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI A. Heather Eliassen · 1985 to 2026
$330.6MTuberous Sclerosis-Pathway and PathogenesisP01CA120964 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI David J. Kwiatkowski · 2007 to 2026
$35.9MTargeting Cancer Through Modifications and MetabolismZIABC011488 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MEIER, JORDAN L · 2013 to 2025
$21.3MDiscovery, Regulation and Function of the PI 3-Kinase and AKT Pathway in CancerR35CA253097 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Alex Toker · 2020 to 2026
$6.9MNovel regulation of PI3K/Akt to direct targeted breast cancer therapiesR01CA177910 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WEI, WENYI · 2013 to 2023
$3.9MRole of Vitamin B5 and Coenzyme A Metabolism in PI3K Driven TumorigenesisR00CA194314 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI DIBBLE, CHRISTIAN · 2018 to 2020
$747kUtilizing Precision Medicine to elucidate the mechanisms underpinning treatment efficacyR00CA230384 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HOPKINS, BENJAMIN D. · 2019 to 2021
$718kRegulation of arginine metabolism as a therapeutic target in breast cancerF31CA213460 · NCI · HARVARD MEDICAL SCHOOL · PI GECK, RENEE CATHERINE · 2017 to 2019
$107kRegulation of the cell cycle and growth signaling pathways by a sensing mechanism for Vitamin B5-Coenzyme A metabolismF31CA254169 · NCI · HARVARD MEDICAL SCHOOL · PI BARRITT, SAMUEL · 2020 to 2022
$83kIntramural NIH HHS ZIA BC011488NCI NIH HHS F31 CA213460NCI NIH HHS F31 CA254169NCI NIH HHS P01 CA120964NCI NIH HHS P30 CA006516NCI NIH HHS R00 CA194314NCI NIH HHS R00 CA230384NCI NIH HHS R01 CA177910NCI NIH HHS R35 CA253097
Abstract
In response to hormones and growth factors, the class I phosphoinositide-3-kinase (PI3K) signalling network functions as a major regulator of metabolism and growth, governing cellular nutrient uptake, energy generation, reducing cofactor production and macromolecule biosynthesis
Indexed as
Coenzyme APantothenic AcidPhosphatidylinositol 3-KinaseAcetyl Coenzyme AAdenosine TriphosphateCell ProliferationCysteineLipid MetabolismMass SpectrometryMetabolomicsPhosphorylationPhosphotransferases (Alcohol Group Acceptor)Proto-Oncogene Proteins c-aktSignal TransductionAcetyl Coenzyme AAdenosine TriphosphateCoenzyme ACysteinepantothenate kinasePantothenic AcidPhosphatidylinositol 3-KinasePhosphotransferases (Alcohol Group Acceptor)Proto-Oncogene Proteins c-akt
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