ReviewNature protocols2022
Single-crystal structure determination of nanosized metal-organic frameworks by three-dimensional electron diffraction.
Review in Nature protocols, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- 3D Electron Diffraction Elucidates the Structure of a 1,3,5-Triazin-2,4-dione Cinnamamide Covalent Inhibitor of SARS-CoV‑2 3CLACS omega · 2026Article
- Programming semiconducting two-dimensional conjugated metal-organic frameworks via anisotropic reticular chemistry.Nature chemistry · 2026Article
- Atomic Coordination Engineering of MOF Nanostructures for COAngewandte Chemie (International ed. in English) · 2026Article
- Single Crystals of Perylene Diimide-Based Two-Dimensional Covalent Organic Frameworks.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- An aqueous in situ approach to discover crystalline coordination materials for adsorptive separation.Nature communications · 2026Article
- In situ electron diffraction tomography study of the successive phase transitions in LaTaONature communications · 2026Article
- Automated Nanocrystalline Sponge Workflow Enabled by 3D Electron Diffraction.Journal of the American Chemical Society · 2026Article
- Multimodal Nanoscale Mapping of Local Structure and COJournal of the American Chemical Society · 2026Article
- Computational Modeling of Reticular Materials: The Past, the Present, and the Future.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Serial Chemical Crystallography for Autonomous Quantitative Phase Analysis in an Electron Microscope.Small methods · 2025Article
- Automated and real-time structure solution using 3D electron diffraction.Journal of applied crystallography · 2025Article
- Reuniting crystallography with real space: Ab initio structure elucidation with 4D-STEM.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A Metal-Organic Polyhedron-to-Coordination Polymer Transition Revealed by 3D Electron Diffraction.Angewandte Chemie (International ed. in English) · 2025Article
- Photo-Assisted Bottom-Up Synthesis of Orange Phosphorus.Angewandte Chemie (International ed. in English) · 2025Article
- Quantum Metal-Organic Frameworks.Small science · 2024Article
- Electron beam and thermal stabilities of MFM-300(M) metal-organic frameworks.Journal of materials chemistry. A · 2024Article
- Single-Crystal Structural Analysis of 2D Metal-Organic Frameworks and Covalent Organic Frameworks by Three-Dimensional Electron Diffraction.Accounts of chemical research · 2024Article
- Article
- Applying 3D ED/MicroED workflows toward the next frontiers.Acta crystallographica. Section C, Structural chemistry · 2024Article
- Advances and applications of microcrystal electron diffraction (MicroED).Current opinion in structural biology · 2024Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metal-organic frameworks (MOFs) have attracted considerable interest due to their well-defined pore architecture and structural tunability on molecular dimensions. While single-crystal X-ray diffraction (SCXRD) has been widely used to elucidate the structures of MOFs at the atomic scale, the formation of large and well-ordered crystals is still a crucial bottleneck for structure determination. To alleviate this challenge, three-dimensional electron diffraction (3D ED) has been developed for structure determination of nano- (submicron-)sized crystals. Such 3D ED data are collected from each single crystal using transmission electron microscopy. In this protocol, we introduce the entire workflow for structural analysis of MOFs by 3D ED, from sample preparation, data acquisition and data processing to structure determination. We describe methods for crystal screening and handling of crystal agglomerates, which are crucial steps in sample preparation for single-crystal 3D ED data collection. We further present how to set up a transmission electron microscope for 3D ED data acquisition and, more importantly, offer suggestions for the optimization of data acquisition conditions. For data processing, including unit cell and space group determination, and intensity integration, we provide guidelines on how to use electron and X-ray crystallography software to process 3D ED data. Finally, we present structure determination from 3D ED data and discuss the important features associated with 3D ED data that need to be considered. We believe that this protocol provides critical details for implementing and utilizing 3D ED as a structure determination platform for nano- (submicron-)sized MOFs as well as other crystalline materials.
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