Evidence map›Paper›PMID 35896734›Full record

ArticleSkeletal radiology2023

Gluteal muscle fatty infiltration, fall risk, and mobility limitation in older women with urinary incontinence: a pilot study.

Derik L Davis, Andrew Roberts, Rodolfo Calderon, Shihyun Kim, Alice S Ryan, Tatiana V D Sanses

Open access · greenAbstract read
In one paragraph

Article in Skeletal radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Human skeletal muscle-specific atrophy with aging: a comprehensive review.Journal of applied physiology (Bethesda, Md. : 1985) · 2023
    Review
  10. Shoulder Dysfunction and Mobility Limitation in Aging.Advances in geriatric medicine and research · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Derik L DavisDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 22 S. Greene Street, Baltimore, MD, 21201, USA. ddavis@som.umaryland.edu.
Andrew RobertsUniversity of Maryland School of Medicine, Baltimore, MD, USA.
Rodolfo CalderonUniversity of Maryland School of Medicine, Baltimore, MD, USA.
Shihyun KimDepartment of Obstetrics and Gynecology, Howard University College of Medicine, Washington, DC, USA.
Alice S RyanDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Tatiana V D SansesDepartment of Obstetrics and Gynecology, Howard University College of Medicine, Washington, DC, USA.
University of Maryland, Baltimore · USHoward University · US

Funding

Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Stephen L. Seliger · 2006 to 2026
$28.9M
Maryland's Organized Research Effort in Women's Health (MORE-WH)K12HD043489 · NICHD · UNIVERSITY OF MARYLAND BALTIMORE · PI TRACY, J. KATHLEEN · 2002 to 2016
$7.0M
Urinary Incontinence, Mobility, Muscle Function in Older WomenR03AG053281 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI SANSES, TATIANA V.D. · 2016 to 2017
$231k
RR&D Research Career Scientist Award ApplicationIK6RX003977 · VA · BALTIMORE VA MEDICAL CENTER · PI ALICE S. RYAN · 2022 to 2026
–
NCATS NIH HHS UL1 TR001409NIA NIH HHS P30 AG028747NIA NIH HHS R03 AG053281NICHD NIH HHS K12 HD043489RRD VA IK6 RX003977
6 · The paper itself

Abstract

objectiveGluteal muscle quality influences risk of falling and mobility limitation. We sought (1) to compare gluteal muscle fatty infiltration (FI) between groups of older women with urinary incontinence (UI) at risk for falling (at-risk group) and not at risk for falling (not-at-risk group), and (2) to determine correlation of gluteal FI with Timed Up and Go (TUG) and Short Physical Performance Battery (SPPB) performance. MATERIALS AND

methodsProspective pilot study of gluteal FI on pelvis MRI for 19 women with UI, aged ≥ 70 years. A musculoskeletal radiologist selected axial T1-weighted MR images; then, two blinded medical student research assistants analyzed gluteal FI by quantitative fuzzy C-means segmentation. TUG and SPPB tests were performed. TUG ≥ 12 s defined participants as at risk for falling. Descriptive, correlation, and reliability analyses were performed.

resultsMean age, 76.3 ± 4.8 years; no difference for age or body mass index (BMI) between the at-risk (n = 5) versus not-at-risk (n = 14) groups. SPPB score (p = 0.013) was lower for the at-risk group (6.4 ± 3.1) than for the not-at-risk group (10.2 ± 1.9). Fuzzy C-means FI-%-estimate differed between the at-risk group and the not-at-risk group for bilateral gluteus medius/minimus (33.2% ± 15.6% versus 19.5% ± 4.1%, p = 0.037) and bilateral gluteus maximus (33.6% ± 15.6% versus 19.7% ± 6.9%, p = 0.047). Fuzzy C-means FI-%-estimate for bilateral gluteus maximus had significant (p < 0.050) moderate correlation with age (rho =  - 0.64), BMI (rho = 0.65), and TUG performance (rho = 0.52). Fuzzy C-means FI-%-estimates showed excellent inter-observer and intra-observer reliability (intraclass correlation coefficient, ≥ 0.892).

conclusionOlder women with UI at risk for falling have greater levels of gluteal FI and mobility limitation as compared to those not at risk for falling.

Indexed as

Mobility LimitationUrinary IncontinenceAgedAged, 80 and overFemaleHumansMuscle, SkeletalPilot ProjectsProspective StudiesReproducibility of ResultsAgingFall riskFuzzy C-meansHipIntramuscular fatty infiltrationMRIUrinary incontinence

Identifiers

PMID35896734
PMCPMC10091062
OpenAlexW4288052775

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.