ArticleNature communications2022
Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression.
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Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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67citing papers in PubMed
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67 citing papers in PubMed, 97 citations in OpenAlex.
- Rethinking cortical hypertrophy in temporal lobe epilepsy.Brain : a journal of neurology · 2026Review
- Age-dependent modulations of hemispheric small-world networks in different eye states: resting-state electroencephalogram research.GeroScience · 2026Article
- Quantifying extra-lesional interhemispheric cortical asymmetry in focal cortical dysplasia type II.Epilepsia open · 2026Article
- Explainable Deep Learning for MRI-Negative Temporal Lobe Epilepsy: Classification and Brain Region Analysis.Diagnostics (Basel, Switzerland) · 2026Article
- Article
- Review
- Volumetric Analysis of Thalamic Nuclei in Epilepsy Patients: A Sex-Based Comparative Study.Diagnostics (Basel, Switzerland) · 2026Article
- Sex-related structural alterations across common epilepsies: a worldwide ENIGMA study.bioRxiv : the preprint server for biology · 2026Article
- Individualized cortical gradient and network topology reveal symptom-linked disruptions and neurobiological subtypes in schizophrenia.medRxiv : the preprint server for health sciences · 2026Article
- Mendelian randomization and clinical retrospective radiomics study reveal causal relationships between brain imaging-derived phenotypes and epilepsy risk.Brain imaging and behavior · 2026Article
- Structural brain imaging biomarkers for predicting seizure recurrence after a first unprovoked seizure.Epilepsia open · 2026Article
- Altered neurostructural development in magnetic resonance imaging-negative pediatric epilepsy: A large-scale multicenter study of 1919 children.Epilepsia · 2026Article
- Abnormal functional connectivity patterns in temporal lobe epilepsy-An international ENIGMA-epilepsy study.Epilepsia open · 2026Article
- Mapping Individualized Dual-Axis Network Topology in Focal Epilepsy: Divergent Alterations in System Integrity, Integration, and Clinical Correlates.bioRxiv : the preprint server for biology · 2026Article
- Orbitofrontal Thickness and Network Associations as Transdiagnostic Signature of Amotivation Along the Bipolar-Schizophrenia Spectrum.Schizophrenia bulletin · 2026Article
- Multimodal integration of magnetic resonance imaging and intracranial electroencephalographic abnormalities in temporal lobe epilepsy surgery.Epilepsia · 2026Article
- A Complex Network-Based Approach for Detecting and Characterizing Power Neurons in Drosophila.Neuroinformatics · 2026Article
- Brain Structural Changes and Cognitive-Clinical Profiles in Late-Onset Unexplained Epilepsy.Neurology · 2026Article
- Associations between epilepsy-related polygenic risk and brain morphology in childhood.Brain : a journal of neurology · 2026Article
- Areas of research priorities in epilepsy: A position paper of the European Reference Network for Rare and Complex Epilepsies, EpiCARE.Epilepsia open · 2026Article
7 more citing papers are in PubMed but not listed here.
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Authors and funding
74 authors at 20 institutions in 14 countries.
Sara LarivièreMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada. sara.lariviere@mail.mcgill.ca.ORCID http://orcid.org/0000-0001-5701-1307
Jessica RoyerMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-4448-8998
Raúl Rodríguez-CrucesMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-2917-1212
Casey PaquolaInstitute for Neuroscience and Medicine (INM-1), Forschungszentrum Jülich, Jülich, Germany.
Maria Eugenia CaligiuriNeuroscience Research Center, University Magna Græcia, Catanzaro, CZ, Italy.
Antonio GambardellaNeuroscience Research Center, University Magna Græcia, Catanzaro, CZ, Italy.ORCID http://orcid.org/0000-0001-7384-3074
Luis ConchaInstitute of Neurobiology, Universidad Nacional Autónoma de México, Querétaro, México.ORCID http://orcid.org/0000-0002-7842-3869
Simon S KellerInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Fernando CendesDepartment of Neurology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.
Clarissa L YasudaDepartment of Neurology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-9084-7173
Leonardo BonilhaDepartment of Neurology, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-6153-8942
Ezequiel GleichgerrchtDepartment of Neurology, Medical University of South Carolina, Charleston, SC, USA.
Niels K FockeDepartment of Neurology, University of Medicine Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0001-5486-6289
Martin DominInstitute of Diagnostic Radiology and Neuroradiology, Functional Imaging Unit, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-8620-966X
Felix von PodewillsDepartment of Neurology, University Medicine Greifswald, Greifswald, Germany.
Soenke LangnerInstitute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
Christian RummelSupport Center for Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Bern, Switzerland.
Roland WiestSupport Center for Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0001-7030-2045
Pascal MartinDepartment of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Raviteja KotikalapudiDepartment of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Terence J O'BrienDepartment of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Melbourne, VIC, Australia.
Benjamin SinclairDepartment of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Melbourne, VIC, Australia.
Lucy VivashDepartment of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Melbourne, VIC, Australia.
Patricia M DesmondDepartments of Medicine and Radiology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia.
Elaine LuiDepartments of Medicine and Radiology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia.
Anna Elisabetta VaudanoNeurology Unit, OCB Hospital, Azienda Ospedaliera-Universitaria, Modena, Italy.
Stefano MelettiNeurology Unit, OCB Hospital, Azienda Ospedaliera-Universitaria, Modena, Italy.
Manuela TondelliDepartment of Biomedical, Metabolic and Neural Science, University of Modena and Reggio Emilia, Modena, Italy.
Saud AlhusainiDepartment of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.
Colin P DohertyDepartment of Neurology, St James' Hospital, Dublin, Ireland.
Gianpiero L CavalleriDepartment of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.
Norman DelantyDepartment of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.
Reetta KälviäinenEpilepsy Center, Neuro Center, Kuopio University Hospital, Member of the European Reference Network for Rare and Complex Epilepsies EpiCARE, Kuopio, Finland.
Graeme D JacksonFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, 3010, Australia.
Magdalena KowalczykFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, 3010, Australia.
Mario MascalchiNeuroradiology Research Program, Meyer Children Hospital of Florence, University of Florence, Florence, Italy.
Mira SemmelrochFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, 3010, Australia.
Rhys H ThomasTransitional and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Hamid Soltanian-ZadehContol and Intelligent Processing Center of Excellence (CIPCE), School of Electrical and Computer Engineering, University of Tehran, Tehran, Iran.ORCID http://orcid.org/0000-0002-7302-6856
Esmaeil Davoodi-BojdDepartment of Neurology, Henry Ford Health System, Detroit, MI, USA.
Junsong ZhangCognitive Science Department, Xiamen University, Xiamen, China.
Gavin P WinstonDivision of Neurology, Department of Medicine, Queen's University, Kingston, ON, Canada.
Aoife GriffinWellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Science, Queens University Belfast, Belfast, UK.ORCID http://orcid.org/0000-0002-9828-5117
Aditi SinghWellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Science, Queens University Belfast, Belfast, UK.
Vijay K TiwariWellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Science, Queens University Belfast, Belfast, UK.ORCID http://orcid.org/0000-0003-0292-6635
Barbara A K KreilkampDepartment of Neurology, University of Medicine Göttingen, Göttingen, Germany.
Matteo LengeChild Neurology Unit and Laboratories, Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Florence, Italy.ORCID http://orcid.org/0000-0003-2848-621X
Renzo GuerriniChild Neurology Unit and Laboratories, Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Florence, Italy.
Khalid HamandiThe Welsh Epilepsy Unit, Department of Neurology, University Hospital of Whales, Cardiff, UK.
Sonya FoleyCardiff University Brain Research Imaging Centre (CUBRIC), College of Biomedical Sciences, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0002-8390-2709
Theodor RüberDepartment of Epileptology, University of Bonn Medical Center, Bonn, Germany.ORCID http://orcid.org/0000-0002-6180-7671
Bernd WeberInstitute of Experimental Epileptology and Cognition Research, University Hospital Bonn, Bonn, Germany.
Chantal DepondtDepartment of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
Julie AbsilDepartment of Radiology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
Sarah J A CarrDivision of Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Eugenio AbelaDivision of Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Mark P RichardsonDivision of Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Orrin DevinskyDepartment of Neurology, NYU Grossman School of Medicine, New York, NY, US.ORCID http://orcid.org/0000-0003-0044-4632
Mariasavina SeverinoIRCCS Istituto Giannina Gaslini, Genova, Italy.
Pasquale StrianoIRCCS Istituto Giannina Gaslini, Genova, Italy.ORCID http://orcid.org/0000-0002-6065-1476
Domenico TortoraDepartment of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy.
Erik KaestnerDepartment of Psychiatry, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, US.
Sean N HattonDepartment of Neurosciences, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, US.ORCID http://orcid.org/0000-0002-9149-8726
Sjoerd B VosDepartment of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK.ORCID http://orcid.org/0000-0002-8502-4487
Lorenzo CaciagliDepartment of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK.
John S DuncanDepartment of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK.ORCID http://orcid.org/0000-0002-1373-0681
Christopher D WhelanDepartment of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.
Paul M ThompsonImaging Genetics Center, Mark & Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, US.
Sanjay M SisodiyaDepartment of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK.
Andrea BernasconiNeuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Angelo LabateNeurology, BIOMORF Dipartment, University of Messina, Messina, Italy.ORCID http://orcid.org/0000-0002-8827-7324
Carrie R McDonaldDepartment of Psychiatry, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, US.
Neda BernasconiNeuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Boris C BernhardtMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada. boris.bernhardt@mcgill.ca.ORCID http://orcid.org/0000-0001-9256-6041
Montreal Neurological Institute and Hospital · CAThe Royal Melbourne Hospital · AURoyal College of Surgeons in Ireland · IEUniversity College London · GBKing's College London · GBMeyer Children's Hospital · ITQueen's University Belfast · GBThe University of Melbourne · AUUniversitätsmedizin Greifswald · DEUniversity of California San Diego · USUniversity of Modena and Reggio Emilia · ITCardiff University · GBHenry Ford Health System · USHertie Institute for Clinical Brain Research · DEIstituto Giannina Gaslini · ITMagna Graecia University · ITUniversidade Estadual de Campinas (UNICAMP) · BRUniversité Libre de Bruxelles · BEUniversity of Göttingen · DEEmory University · US
Funding
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1MTraining U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MFellowship on Biological Psychiatry and NeuroscienceT32MH018399 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pei-an (Betty) Shih · 1986 to 2026
$7.3MLifespan Epilepsy Network Signatures (LENS): Leveraging ENIGMA-Epilepsy to Predict Cognitive Aging and Surgical OutcomesR01NS122827 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CARRIE R MCDONALD · 2021 to 2026
$3.8MDefining the Epileptogenic Network and Identifying Which Components Generate SeizuresR01NS106957 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Richard Staba · 2018 to 2026
$3.4MPrediction of seizure lateralization and postoperative outcome through the use of deep learning applied to multi-site MRI/DTI data: An ENIGMA-Epilepsy studyR21NS107739 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BONILHA, LEONARDO F, MCDONALD, CARRIE R · 2019 to 2019
$444kMedical Research Council G080212Medical Research Council MR/K013998/1Medical Research Council MR/M00841X/1Medical Research Council MR/S00355X/1NIBIB NIH HHS P41 EB015922NIBIB NIH HHS U54 EB020403NIMH NIH HHS T32 MH018399NINDS NIH HHS R01 NS106957NINDS NIH HHS R01 NS122827NINDS NIH HHS R21 NS107739
Abstract
Epilepsy is associated with genetic risk factors and cortico-subcortical network alterations, but associations between neurobiological mechanisms and macroscale connectomics remain unclear. This multisite ENIGMA-Epilepsy study examined whole-brain structural covariance networks in patients with epilepsy and related findings to postmortem epilepsy risk gene expression patterns. Brain network analysis included 578 adults with temporal lobe epilepsy (TLE), 288 adults with idiopathic generalized epilepsy (IGE), and 1328 healthy controls from 18 centres worldwide. Graph theoretical analysis of structural covariance networks revealed increased clustering and path length in orbitofrontal and temporal regions in TLE, suggesting a shift towards network regularization. Conversely, people with IGE showed decreased clustering and path length in fronto-temporo-parietal cortices, indicating a random network configuration. Syndrome-specific topological alterations reflected expression patterns of risk genes for hippocampal sclerosis in TLE and for generalized epilepsy in IGE. These imaging-transcriptomic signatures could potentially guide diagnosis or tailor therapeutic approaches to specific epilepsy syndromes.
Indexed as
ConnectomeEpilepsyEpilepsy, GeneralizedEpilepsy, Temporal LobeAdultGene ExpressionHumansImmunoglobulin EMagnetic Resonance ImagingNerve NetImmunoglobulin E
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