Evidence map›Paper›PMID 35896521›Full record

ArticleNature communications2022

Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice.

André A Weber, Xiaojing Yang, Elvira Mennillo, Jeffrey Ding, Jeramie D Watrous, Mohit Jain, Shujuan Chen, Michael Karin, Robert H Tukey

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

André A WeberLaboratory of Environmental Toxicology, Department of Pharmacology, University of California, San Diego, La Jolla, CA, 92093, USA.
Xiaojing YangLaboratory of Environmental Toxicology, Department of Pharmacology, University of California, San Diego, La Jolla, CA, 92093, USA.
Elvira MennilloLaboratory of Environmental Toxicology, Department of Pharmacology, University of California, San Diego, La Jolla, CA, 92093, USA.
Jeffrey DingDepartments of Medicine and Pharmacology, University of California, San Diego, La Jolla, CA, 92093, USA.
Jeramie D WatrousDepartments of Medicine and Pharmacology, University of California, San Diego, La Jolla, CA, 92093, USA.
Mohit JainDepartments of Medicine and Pharmacology, University of California, San Diego, La Jolla, CA, 92093, USA.
Shujuan ChenLaboratory of Environmental Toxicology, Department of Pharmacology, University of California, San Diego, La Jolla, CA, 92093, USA.
Michael KarinLaboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, La Jolla, CA, 92093, USA.
Robert H TukeyLaboratory of Environmental Toxicology, Department of Pharmacology, University of California, San Diego, La Jolla, CA, 92093, USA. rtukey@health.ucsd.edu.ORCID 0000-0001-9683-4226
University of California San Diego · US

Funding

Yeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8M
Control of Lipogenesis and Hepatic Steatosis by Caspase-2R01DK120714 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Michael Karin · 2019 to 2026
$4.0M
Severe neonatal hyperbilirubinemia (SNH) and the expression of UDP-glucuronosyltransferase 1A1 (UGT1A1) play key roles in the development of necrotizing enterocolitis (NEC)R01DK136599 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Robert H Tukey · 2023 to 2026
$2.5M
Lifelong Triclosan Exposure and Fatty Liver DiseaseR21ES031849 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2020 to 2021
$434k
NIDDK NIH HHS R01 DK120714NIDDK NIH HHS R01 DK136599NIEHS NIH HHS P42 ES010337NIEHS NIH HHS R21 ES031849
6 · The paper itself

Abstract

Here we show that Triclosan (TCS), a high-volume antimicrobial additive that has been detected in human breastmilk, can be efficiently transferred by lactation to newborn mice, causing significant fatty liver (FL) during the suckling period. These findings are relevant since pediatric non-alcoholic fatty liver disease (NAFLD) is escalating in the United States, with a limited mechanistic understanding. Lactational delivery stimulated hepatosteatosis, triglyceride accumulation, endoplasmic reticulum (ER) stress, signs of inflammation, and liver fibrosis. De novo lipogenesis (DNL) induced by lactational TCS exposure is shown to be mediated in a PERK-eIF2α-ATF4-PPARα cascade. The administration of obeticholic acid (OCA), a potent FXR agonist, as well as activation of intestinal mucosal-regenerative gp130 signaling, led to reduced liver ATF4 expression, PPARα signaling, and DNL when neonates were exposed to TCS. It is yet to be investigated but mother to child transmission of TCS or similar toxicants may underlie the recent increases in pediatric NAFLD.

Indexed as

Non-alcoholic Fatty Liver DiseaseTriclosanAnimalsAnimals, NewbornChildFemaleHumansInfectious Disease Transmission, VerticalLactationLipogenesisLiverMiceMice, Inbred C57BLPPAR alphaPPAR alphaTriclosan

Identifiers

PMID35896521
PMCPMC9329322
OpenAlexW4288051290

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.