ArticleApplied clinical informatics2022
Real-World Matching Performance of Deidentified Record-Linking Tokens.
Article in Applied clinical informatics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Enhancing Evidence Generation by Linking Randomized Clinical Trials to Real-World Data: The INVESTED-Medicare Linkage Study.Clinical pharmacology and therapeutics · 2026Article
- A Real-World Target Trial Emulation of Eteplirsen, Casimersen, and Golodirsen to Evaluate Survival Among Patients with Duchenne Muscular Dystrophy.Advances in therapy · 2026Article
- Accuracy of an XGBoost-based privacy preserving record linkage system compared with an electronic health record patient matching module in identifying patients shared between nearby academic health centers.Journal of the American Medical Informatics Association : JAMIA · 2026Article
- Outcomes and Management of Pregnancies Screening Positive for Microdeletions 22q11.2, 15q11.2, 1p36, 4p, or 5p: A Retrospective Cohort Study.The application of clinical genetics · 2026Article
- Article
- Linking clinical trial data with real-world data for enhanced clinical evidence generation: methodological considerations and recommendations.Frontiers in pharmacology · 2026Review
- Combining Real-World and Clinical Trial Data Through Privacy-Preserving Record Linkage: Opportunities and Challenges-A Narrative Review.Health science reports · 2025Article
- Screening Positive for Rare Autosomal Aneuploidies Increases Frequency of Adverse Pregnancy Outcomes and Alters Clinical Management.Prenatal diagnosis · 2025Article
- Enabling secure and self determined health data sharing and consent management.NPJ digital medicine · 2025Review
- Real-world pharmacotherapy treatment patterns among patients diagnosed with postpartum depression in the United States.BMC psychiatry · 2025Article
- Longitudinal Relationship Between Elevated Liver Biochemical Tests and Negative Clinical Outcomes in Primary Biliary Cholangitis: A Population-Based Study.Alimentary pharmacology & therapeutics · 2025Article
- Association of Polygenic-Based Breast Cancer Risk Prediction With Patient Management.JCO precision oncology · 2025Article
- Burden of illness for patients with primary biliary cholangitis: an observational study of clinical characteristics and healthcare resource utilization.Journal of comparative effectiveness research · 2025Observational
- Linkage of Clinical Trial Data to Routinely Collected Data Sources: A Scoping Review.JAMA network open · 2025Article
- Accuracy of privacy preserving record linkage for real world data in the United States: a systemic review.JAMIA open · 2025Review
- Tokenization techniques for privacy-preserving healthcare data: tokenization nuts and bolts.Frontiers in drug safety and regulation · 2025Review
- Implementing tokenization in clinical research to expand real-world insights.Frontiers in drug safety and regulation · 2025Article
- Privacy preserving record linkage for public health action: opportunities and challenges.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- Linking clinical trial participants to their U.S. real-world data through tokenization: A practical guide.Contemporary clinical trials communications · 2024Article
- Adherence and persistence to tafamidis treatment among Medicare beneficiaries in the presence of a patient assistance program.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveOur objective was to evaluate tokens commonly used by clinical research consortia to aggregate clinical data across institutions.
methodsThis study compares tokens alone and token-based matching algorithms against manual annotation for 20,002 record pairs extracted from the University of Texas Houston's clinical data warehouse (CDW) in terms of entity resolution.
resultsThe highest precision achieved was 99.9% with a token derived from the first name, last name, gender, and date-of-birth. The highest recall achieved was 95.5% with an algorithm involving tokens that reflected combinations of first name, last name, gender, date-of-birth, and social security number. DISCUSSION: To protect the privacy of patient data, information must be removed from a health care dataset to obscure the identity of individuals from which that data were derived. However, once identifying information is removed, records can no longer be linked to the same entity to enable analyses. Tokens are a mechanism to convert patient identifying information into Health Insurance Portability and Accountability Act-compliant deidentified elements that can be used to link clinical records, while preserving patient privacy.
conclusionDepending on the availability and accuracy of the underlying data, tokens are able to resolve and link entities at a high level of precision and recall for real-world data derived from a CDW.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.